DNAJA3 cdna clone
DNAJA3 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Uniprot Description
DNAJA3: Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. Interacts with JAK2, HSPA9B and IFN-gammaR2 chain. Interacts with Ras GTPase-activating protein 1 (RASA1). Isoform 2 interacts with MUSK (via the cytoplasmic domain). Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; Chaperone; Cell cycle regulation; Apoptosis
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: actin filament; extrinsic to plasma membrane; intracellular membrane-bound organelle; mitochondrial matrix; mitochondrion; neuromuscular junction; postsynaptic membrane
Molecular Function: protein binding
Biological Process: mitochondrion organization and biogenesis; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter
Research Articles on DNAJA3
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Product Notes
The DNAJA3 dnaja3 (Catalog #AAA1277098) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggctgcgc ggtgctccac acgctggttg ctggtggttg tggggacccc gcggctgccg gctatatcgg gtagaggggc ccggccgccc agggagggcg tggtgggggc atggctgagc cgcaagctga gcgtccccgc ctttgcgtct tccctgacct cttgcggccc ccgagcgctg ctgacattga gacctggtgt cagcctcaca ggaacaaaac attacccttt catttgtact gcctccttcc acacgagtgc ccctttggcc aaagaagatt attatcagat attaggagtg cctcgaaatg ccagccagaa agagatcaag aaagcctatt atcagcttgc caagaagtat caccctgaca caaataagga tgatcccaaa gccaaggaga agttctccca gctggcagaa gcctatgagg ttttgagtga tgaggtgaag aggaagcagt acgatgccta cggctctgca ggcttcgatc ctggggccag cggctcccag catagctact ggaagggagg ccccactgtg gaccccgagg agctgttcag gaagatcttt ggcgagttct catcctcttc atttggagat ttccagaccg tgtttgatca gcctcaggaa tacttcatgg agttgacatt caatcaagct gcaaaggggg tcaacaagga gttcaccgtg aacatcatgg acacgtgtga gcgctgcaac ggcaagggga acgagcccgg caccaaggtg cagcattgcc actactgtgg cggctccggc atggaaacca tcaacacagg cccttttgtg atgcgttcca cgtgtaggag atgtggtggc cgcggctcca tcatcatatc gccctgtgtg gtctgcaggg gagcaggaca agccaagcag aaaaagcgag tgatgatccc tgtgcctgca ggagtcgagg atggccagac cgtgaggatg cctgtgggaa aaagggaaat tttcattacg ttcagggtgc agaaaagccc tgtgttccgg agggacggcg cagacatcca ctccgacctc tttatttcta tagctcaggc tcttcttggg ggaacagcca gagcccaggg cctgtacgag acgatcaacg tgacgatccc ccctgggact cagacagacc agaagattcg gatgggtggg aaaggcatcc cccggattaa cagctacggc tacggagacc actacatcca catcaagata cgagttccaa agaggctaac gagccggcag cagagcctga tcctgagcta cgccgaggac gagacagatg tggaggggac ggtgaacggc gtcaccctca ccagctctgg aaaaagatcc actggaaact ag. It is sometimes possible for the material contained within the vial of "DNAJA3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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