DIO1 cdna clone
DIO1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein is expressed predominantly in the liver and kidney and provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2016]
Uniprot Description
DIO1: Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney. Belongs to the iodothyronine deiodinase family. 9 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.97.1.10; Membrane protein, integral; Oxidoreductase
Chromosomal Location of Human Ortholog: 1p33-p32
Cellular Component: plasma membrane
Molecular Function: selenium binding; thyroxine 5'-deiodinase activity
Biological Process: thyroid hormone generation
Research Articles on DIO1
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Product Notes
The DIO1 dio1 (Catalog #AAA1269685) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGGGCTGC CCCAGCCAGG GCTGTGGCTG AAGAGGCTCT GGGTGCTCTT GGAGGTGGCT GTGCATGTGG TCGTGGGTAA AGTGCTTCTG ATATTGTTTC CAGACAGAGT CAAGCGGAAC ATCCTGGCCA TGGGCGAGAA GACGGGTATG ACCAGGAACC CCCATTTCAG CCACGACAAC TGGATACCAA CCTTTTTCAG CACCCAGTAT TTCTGGTTCG TCTTGAAGGT CCGTTGGCAG CGACTAGAGG ACACGACTGA GCTAGGGGGT CTGGCCCCAA ACTGCCCGGT GGTCCGCCTC TCAGGACAGA GGTGCAACAT TTGGGAGTTT ATGCAAGGTA ATAGGCCACT GGTGCTGAAT TTTGGAAGTT GTACCTGACC TTCATTTATG TTCAAATTTG ACCAGTTCAA GAGGCTTATT GAAGACTTTA GTTCCATAGC AGATTTTCTT GTCATTTACA TTGAAGAAGC ACATGCATCA GATGGCTGGG CTTTTAAGAA CAACATGGAC ATCAGAAATC ACCAGAACCT TCAGGATCGC CTGCAGGCAG CCCATCTACT GCTGGCCAGG AGCCCCCAGT GCCCTGTGGT GGTGGACACC ATGCAGAACC AGAGCAGCCA GCTCTACGCA GCACTGCCTG AGAGGCTCTA CATAATCCAG GAGGGCAGGA TCCTCTACAA GGGTAAATCT GGCCCTTGGA ACTACAACCC AGAGGAAGTT CGTGCTGTTC TGGAAAAGCT CCACAGTTAA. It is sometimes possible for the material contained within the vial of "DIO1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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