DHTKD1 cdna clone

DHTKD1 cDNA Clone

Gene Names

DHTKD1; CMT2Q; AMOXAD

Synonyms

DHTKD1; DHTKD1 cDNA Clone; DHTKD1 cdna clone

Ordering
Cat. Num. AAA1278738 For Research Use Only!

Sequence

atggcctctgctactgcggcagcagcacgacggggcctcggccgggctctccctctcctctggcgtggctaccagaccgagcggggcgtttacggctaccggccgaggaagcccgagagccgcgagccccagggcgccctggagcgccccccagttgatcatggccttgccaggttggtgacagtatattgtgagcatggtcataaagctgccaaaatcaaccccctcttcaccggacaagccctgctggagaatgtgcctgaaatccaagccctggtgcagacactgcagggacccttccacacggcaggattattgaacatggggaaggaagaggcctcacttgaggaagtgttagtctatctcaatcaaatctactgtgggcagatttctattgaaacctcccaacttcagagccaggatgagaaagactggtttgccaagcggtttgaggaactgcaaaaggagacgtttaccacagaagagcgaaaacatctgtcgaaactaatgctggaatctcaggagtttgaccactttctggccaccaagttctcgacagtgaagcgatatggaggcgaaggggctgaaagcatgatgggctttttccacgagctgctgaaaatgtcggcctacagcgggatcactgatgtcattattgggatgccccatagagggaggctgaatttattgacaggccttctgcagttccctccagagctgatgttccgtaaaatgcgaggcttaagtgaatttccagagaatttctcagccactggagacgtcctgtctcacctgacctcctctgtggacctggactttggggcgcaccatcccctccatgtgacaatgttgcccaatccctcgcacctggaggccgtcaaccccgtggccgtgggcaaaactcgcggcaggcagcagtctctccaagacggcgattactctccagacaactcagcccagccgggggacagggtcatttgcttacaggtccatggtgatgcttctttctgtggtcaagggattgttcctgaaacattcacgctgtccaatctcccacatttcagaattggtgggagtgtgcatttgattgttaataaccagctgggttacaccactccagctgaaagaggaaggtcttctttatactgcagtgatattgggaagcttgtgggctgtgccatcatccatgtcaatggagacagcccagaggaagtggtccgtgccacacgactggcttttgaataccaacgccagttccgcaaggatgtgattattgatctgttgtgctacaggcagtggggccacaatgagctggatgagccattctacaccaaccccatcatgtacaaaatcatcagagctcgaaagagcattccagacacatatgcagagcacctcattgctggcggactcatgacgcaggaggaggtgtctgaaataaaatcctcctactatgccaagttgaatgatcacttaaataacatggcccactacaggccccctgccctgaacctgcaggcccactggcagggcctggctcagccagaagcgcaaatcaccacctggagtacaggtgtgcccctcgacctcctgcggtttgttggcatgaagtctgtagaggtgccaagagagctgcagatgcacagtcacctgctgaagacacatgttcagtccagaatggagaagatgatggacggaatcaagctagactgggccaccgcggaagctcttgccttgggttctttacttgctcaaggttttaatgttcgtctaagtggccaagatgttggtcgtggaactttcagtcagaggcatgcaatggtggtttgccaggagacggatgacacctacatccccctgaaccatatggacccaaatcagaaggggtttctagaggtcagcaacagccccctgtcagaagaggccgtcctgggattcgaatatgggatgagcattgagagcccaaagttactgcccctgtgggaggcacagtttggcgatttcttcaatggtgcccagatcatctttgacacattcatctctggaggagaggccaagtggctcctacaaagcggcattgtcatcctccttccacatggctacgatggggctgggccagaccactcatcctgtcgaatagagcgtttcctgcagatgtgtgacagtgcggaagagggggtggacggagacactgtgaacatgtttgtggttcacccaacaactcctgcacagtatttccacttgcttaggagacagatggtccggaacttcagaaaaccactcattgttgcttcccctaagatgttactcaggctcccggcagccgtgtcaactcttcaagaaatggcaccaggaacaacatttaacccggtcattggtgattcatctgtggatccaaaaaaggttaagaccctcgtgttctgctccggcaaacatttctactccctggtgaaacaaagagaatctctgggggccaagaagcatgactttgccatcatccgagtagaggaactctgccccttcccgttggattctttacagcaagagatgagcaaatacaaacatgttaaagatcatatttggagtcaggaggaacctcagaacatgggtccgtggtcgtttgtttctccaaggtttgaaaagcagctggcctgcaagctccgtctggtgggccggccccctttgccagtacccgctgtaggaattggcacagttcacttgcaccagcatgaagatatcctcgccaagaccttcgcttga

Sequence Length

2760

Vector

Please Inquire

NCBI and Uniprot Product Information

NCBI GI #

33876732

NCBI GeneID

55526

Molecular Weight

103,077 Da

NCBI Official Full Name

Homo sapiens dehydrogenase E1 and transketolase domain containing 1, mRNA

NCBI Official Synonym Full Names

dehydrogenase E1 and transketolase domain containing 1

NCBI Official Symbol

DHTKD1

NCBI Official Synonym Symbols

CMT2Q; AMOXAD

NCBI Protein Information

probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

UniProt Protein Name

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

Protein Family

Probable 2-oxoglutarate dehydrogenase E1 component

UniProt Gene Name

DHTKD1

UniProt Synonym Gene Names

KIAA1630

UniProt Entry Name

DHTK1_HUMAN

NCBI Description

This gene encodes a component of a mitochondrial 2-oxoglutarate-dehydrogenase-complex-like protein involved in the degradation pathways of several amino acids, including lysine. Mutations in this gene are associated with 2-aminoadipic 2-oxoadipic aciduria and Charcot-Marie-Tooth Disease Type 2Q. [provided by RefSeq, May 2013]

Uniprot Description

DHTKD1: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). Belongs to the alpha-ketoglutarate dehydrogenase family.

Protein type: Oxidoreductase; EC 1.2.4.2

Chromosomal Location of Human Ortholog: 10p14

Cellular Component: cytosol; mitochondrial matrix; mitochondrion; oxoglutarate dehydrogenase complex

Molecular Function: oxoglutarate dehydrogenase (succinyl-transferring) activity

Biological Process: generation of precursor metabolites and energy; glyoxylate metabolic process; tricarboxylic acid cycle

Disease: 2-aminoadipic 2-oxoadipic Aciduria; Charcot-marie-tooth Disease, Axonal, Type 2q

Research Articles on DHTKD1

1. DHTKD1 encodes the E1 subunit of the alpha-ketoadipic acid dehydrogenase complex

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Product Notes

The DHTKD1 dhtkd1 (Catalog #AAA1278738) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcctctg ctactgcggc agcagcacga cggggcctcg gccgggctct ccctctcctc tggcgtggct accagaccga gcggggcgtt tacggctacc ggccgaggaa gcccgagagc cgcgagcccc agggcgccct ggagcgcccc ccagttgatc atggccttgc caggttggtg acagtatatt gtgagcatgg tcataaagct gccaaaatca accccctctt caccggacaa gccctgctgg agaatgtgcc tgaaatccaa gccctggtgc agacactgca gggacccttc cacacggcag gattattgaa catggggaag gaagaggcct cacttgagga agtgttagtc tatctcaatc aaatctactg tgggcagatt tctattgaaa cctcccaact tcagagccag gatgagaaag actggtttgc caagcggttt gaggaactgc aaaaggagac gtttaccaca gaagagcgaa aacatctgtc gaaactaatg ctggaatctc aggagtttga ccactttctg gccaccaagt tctcgacagt gaagcgatat ggaggcgaag gggctgaaag catgatgggc tttttccacg agctgctgaa aatgtcggcc tacagcggga tcactgatgt cattattggg atgccccata gagggaggct gaatttattg acaggccttc tgcagttccc tccagagctg atgttccgta aaatgcgagg cttaagtgaa tttccagaga atttctcagc cactggagac gtcctgtctc acctgacctc ctctgtggac ctggactttg gggcgcacca tcccctccat gtgacaatgt tgcccaatcc ctcgcacctg gaggccgtca accccgtggc cgtgggcaaa actcgcggca ggcagcagtc tctccaagac ggcgattact ctccagacaa ctcagcccag ccgggggaca gggtcatttg cttacaggtc catggtgatg cttctttctg tggtcaaggg attgttcctg aaacattcac gctgtccaat ctcccacatt tcagaattgg tgggagtgtg catttgattg ttaataacca gctgggttac accactccag ctgaaagagg aaggtcttct ttatactgca gtgatattgg gaagcttgtg ggctgtgcca tcatccatgt caatggagac agcccagagg aagtggtccg tgccacacga ctggcttttg aataccaacg ccagttccgc aaggatgtga ttattgatct gttgtgctac aggcagtggg gccacaatga gctggatgag ccattctaca ccaaccccat catgtacaaa atcatcagag ctcgaaagag cattccagac acatatgcag agcacctcat tgctggcgga ctcatgacgc aggaggaggt gtctgaaata aaatcctcct actatgccaa gttgaatgat cacttaaata acatggccca ctacaggccc cctgccctga acctgcaggc ccactggcag ggcctggctc agccagaagc gcaaatcacc acctggagta caggtgtgcc cctcgacctc ctgcggtttg ttggcatgaa gtctgtagag gtgccaagag agctgcagat gcacagtcac ctgctgaaga cacatgttca gtccagaatg gagaagatga tggacggaat caagctagac tgggccaccg cggaagctct tgccttgggt tctttacttg ctcaaggttt taatgttcgt ctaagtggcc aagatgttgg tcgtggaact ttcagtcaga ggcatgcaat ggtggtttgc caggagacgg atgacaccta catccccctg aaccatatgg acccaaatca gaaggggttt ctagaggtca gcaacagccc cctgtcagaa gaggccgtcc tgggattcga atatgggatg agcattgaga gcccaaagtt actgcccctg tgggaggcac agtttggcga tttcttcaat ggtgcccaga tcatctttga cacattcatc tctggaggag aggccaagtg gctcctacaa agcggcattg tcatcctcct tccacatggc tacgatgggg ctgggccaga ccactcatcc tgtcgaatag agcgtttcct gcagatgtgt gacagtgcgg aagagggggt ggacggagac actgtgaaca tgtttgtggt tcacccaaca actcctgcac agtatttcca cttgcttagg agacagatgg tccggaactt cagaaaacca ctcattgttg cttcccctaa gatgttactc aggctcccgg cagccgtgtc aactcttcaa gaaatggcac caggaacaac atttaacccg gtcattggtg attcatctgt ggatccaaaa aaggttaaga ccctcgtgtt ctgctccggc aaacatttct actccctggt gaaacaaaga gaatctctgg gggccaagaa gcatgacttt gccatcatcc gagtagagga actctgcccc ttcccgttgg attctttaca gcaagagatg agcaaataca aacatgttaa agatcatatt tggagtcagg aggaacctca gaacatgggt ccgtggtcgt ttgtttctcc aaggtttgaa aagcagctgg cctgcaagct ccgtctggtg ggccggcccc ctttgccagt acccgctgta ggaattggca cagttcactt gcaccagcat gaagatatcc tcgccaagac cttcgcttga. It is sometimes possible for the material contained within the vial of "DHTKD1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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DHTKD1 cdna clone