DERL2 cdna clone
DERL2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[supplied by OMIM, Mar 2008]
Uniprot Description
DERL2: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation. Belongs to the derlin family.
Protein type: Membrane protein, multi-pass; Endoplasmic reticulum; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17p13.2
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; membrane
Molecular Function: protein binding
Biological Process: ER-associated protein catabolic process; positive regulation of cell growth; positive regulation of cell proliferation; retrograde protein transport, ER to cytosol; unfolded protein response
Research Articles on DERL2
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Product Notes
The DERL2 derl2 (Catalog #AAA1273664) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcgtacc agagcttgcg gctggagtac ctgcagatcc caccggtcag ccgcgcctac accactgcct gcgtcctcac caccgccgcc gtgcagttgg aattgatcac accttttcag ttgtacttca atcctgaatt aatctttaaa cactttcaaa tatggagatt aatcaccaac ttcttatttt ttgggccagt tggattcaat tttttattta acatgatttt tctatatcgt tactgtcgaa tgctagaaga aggctctttc cgaggtcgga cagcagactt tgtatttatg ttcctttttg gtggattctt aatgaccctt tttggtctgt ttgtgagctt agttttcttg ggccaggcct ttacaataat gctcgtctat gtgtggagcc gaaggaaccc ctatgtccgc atgaacttct tcggccttct caacttccag gccccctttc tgccctgggt gctcatggga ttttccttgt tgttggggaa ctcaatcatt gtggaccttt tgggtattgc agttggacac atatattttt tcttggaaga tgtatttccc aatcaacctg gtggaataag aattctgaaa acaccatcta ttttgaaagc tatttttgat acaccagatg aggatccaaa ttacaatcca ctacctgagg aacggccagg aggcttcgcc tggggtgagg gccagcggct tggaggttaa. It is sometimes possible for the material contained within the vial of "DERL2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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