DDX23 cdna clone
DDX23 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
DDX23: Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Protein type: RNA splicing; EC 3.6.4.13; RNA processing; Helicase; Spliceosome; RNA-binding
Chromosomal Location of Human Ortholog: 12q13.12
Cellular Component: nucleolus; nucleoplasm; nucleus; snRNP U5
Molecular Function: ATP-dependent helicase activity; ATP-dependent RNA helicase activity; protein binding
Biological Process: cis assembly of pre-catalytic spliceosome; nuclear mRNA splicing, via spliceosome; RNA secondary structure unwinding; RNA splicing; RNA splicing, via transesterification reactions
Research Articles on DDX23
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Product Notes
The DDX23 ddx23 (Catalog #AAA1269981) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcaggag agctggctga caaaaaggac cgtgatgcat caccttccaa ggaggaaagg aagcgatcac ggactcctga cagagagcgg gatagagacc gggaccggaa gtcttcccca tctaaagata gaaagcggca tcgttcaagg gatagacgtc gaggaggcag ccgttctcgc tctcgttccc gttccaaatc tgcagaaaga gaacgacggc acaaagaacg agaacgagat aaggagcggg atcggaataa gaaggaccga gatcgagaca aggatgggca cagacgggac aaggaccgta aacgatccag cttatctcct ggtcgaggaa aagactttaa atctcggaag gacagagact ctaagaagga tgaagaggat gaacatggtg ataagaagcc taaggcccag ccattatccc tggaggagct tctggccaag aaaaaggctg aggaagaagc tgaggctaag cccaagttcc tctctaaagc agaacgagag gctgaagctc taaagcgacg gcagcaggag gtggaagagc ggcagaggat gcttgaagaa gagaggaaga aaaggaaaca gttccaagac ttgggcagga agatgttgga agatcctcag gaacgggaac gtcgggaacg cagggagagg atggaacggg agaccaatgg aaatgaggat gaggaagggc ggcagaagat ccgggaagag aaggataaga gcaaggaact gcatgccatt aaggagcgtt acctgggtgg catcaaaaag cggcgccgaa cgagacatct caatgaccgg aaatttgttt ttgagtggga tgcatctgag gacacatcca ttgactacaa ccccctgtac aaagaacggc accaggtgca gttgttaggg cgaggcttca ttgcaggcat tgacctcaag cagcagaagc gagagcagtc acgtttctat ggagacctaa tggagaagag gcgaaccctg gaagaaaagg agcaggagga ggcaagactc cgcaaacttc gtaagaagga agccaagcag cgctgggatg atcgtcattg gtctcagaaa aagttagatg agatgacgga cagggactgg cggatcttcc gtgaggacta cagcatcacc accaaaggtg gcaagatccc caatcccatc cgatcctgga aagactcttc tctgccccca cacatcttgg aggtcattga taagtgtggc tacaaggaac caacacctat acagcgtcag gcaattccca ttgggctaca gaatcgtgac atcattggtg tggctgagac tggcagtggc aagacagcag ccttcctcat ccctctgctg gtctggatca ccacacttcc caaaattgac aggatcgaag agtcagacca aggcccttat gccatcatcc tggctcccac ccgtgagttg gctcaacaga ttgaggaaga gaccatcaag tttgggaaac cgctaggtat ccgcactgtg gctgtcattg gtggcatctc cagagaagac cagggcttca ggctgcgcat gggttgtgag attgtgattg ctacccctgg gcgtttgatt gatgtgctgg agaaccgcta cctggtgctg agccgctgta cctatgtggt tctggatgag gcagatagga tgattgacat gggctttgag ccagatgtcc agaagatcct ggagcacatg cctgtcagca accagaagcc agacacggat gaggctgagg accctgagaa gatgctggcc aactttgagt cgggaaaaca taagtaccgc caaacagtca tgttcacggc caccatgccc ccagcggtgg agcgtctggc caggagctat cttcggcgac ctgctgtggt gtacattggc tccgcaggca agccccatga gcgtgtggaa cagaaggtct tcctcatgtc agagtcagaa aagaggaaaa agctgctggc aatcttggag caaggctttg acccacccat cattattttt gtcaaccaga agaagggctg cgacgtgttg gccaaatccc tggagaagat ggggtacaat gcttgcacac tgcacggtgg aaaaggccag gagcagcgag agtttgcgtt gtccaacctc aaggctgggg ccaaggatat tttggtggct acagatgtgg ctggtcgtgg tattgacatc caagatgtgt ctatggttgt caactatgat atggccaaaa atattgaaga ttacatccac cgcattggcc gcacgggacg agcaggcaag agtggggtgg ccatcacctt cctcacaaaa gaggactctg ctgtgttcta cgagctgaag caagctatcc tggaaagccc agtgtcttcc tgtccccccg aactagccaa ccacccagat gcccagcata agccaggcac catcctcacc aagaagcgcc gggaagagac catctttgcc tga. It is sometimes possible for the material contained within the vial of "DDX23, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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