Rabbit anti-Human UROC1 Polyclonal Antibody | anti-UROC1 antibody

UROC1, ID (UROC1, Urocanate hydratase, Imidazolonepropionate hydrolase) (APC)

Cat. Num. AAA6361752

• Gene Names: UROC1; UROCD; HMFN0320
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: UROC1; Polyclonal Antibody; ID (UROC1; Urocanate hydratase; Imidazolonepropionate hydrolase) (APC); Imidazolonepropionate hydrolase; anti-UROC1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-UROC1 antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:10-50; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: UROC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 409-437 amino acids from the Central region of human UROC1.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(UROC1 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the UROC1 antibody detected the UROC1 protein (arrow).)

Immunohistochemistry (IHC)

(UROC1 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of UROC1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-UROC1 antibody

This gene encodes an enzyme involved in histidine catabolism, metabolizing urocanic acid to formiminoglutamic acid. The gene product is known to protect the skin from ultra violet rays and is contained in human sweat. Deficiency of this gene product in the liver is an apparent cause of mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-UROC1 antibody

Antibodies; Enzymes

References

Espinos, C., et al. J. Med. Genet. 46(6):407-411(2009). Yamada, S., et al. Oncogene 23(35):5901-5911(2004). Retey, J. Arch. Biochem. Biophys. 314(1):1-16(1994) Kalafatic, Z., et al. Metab. Clin. Exp. 29(11):1013-1019(1980).

NCBI and Uniprot Product Information

• NCBI GI #: 21389467
• NCBI GeneID: 131669
• NCBI Accession #: NP_653240.1; NP_001159446.1
• NCBI GenBank Nucleotide #: NM_144639.2
• UniProt Accession #: Q96N76; Q14C64; Q68CJ7; E9PE13
• Molecular Weight: 80,912 Da
• NCBI Official Full Name: urocanate hydratase isoform 1
• NCBI Official Synonym Full Names: urocanate hydratase 1
• NCBI Official Symbol: UROC1
• NCBI Official Synonym Symbols: UROCD; HMFN0320
• NCBI Protein Information: urocanate hydratase
• UniProt Protein Name: Urocanate hydratase
• UniProt Gene Name: UROC1
• UniProt Synonym Gene Names: Urocanase

NCBI Description

This gene encodes an enzyme involved in histidine catabolism, metabolizing urocanic acid to formiminoglutamic acid. The gene product is known to protect the skin from ultra violet rays and is contained in human sweat. Deficiency of this gene product in the liver is an apparent cause of mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]