CX3CR1 cdna clone
CX3CR1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Uniprot Description
CX3CR1: Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1. Defects in CX3CR1 are a cause of susceptibility to age- related macular degeneration type 12 (ARMD12). ARMD12 is a form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Receptor, GPCR; Membrane protein, multi-pass; Motility/polarity/chemotaxis; GPCR, family 1; Receptor, cytokine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3p21.3
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: C-X3-C chemokine binding; chemokine receptor activity; protein binding
Biological Process: cellular defense response; chemotaxis; response to wounding
Disease: Coronary Heart Disease, Susceptibility To, 1; Human Immunodeficiency Virus Type 1, Susceptibility To; Macular Degeneration, Age-related, 12
Research Articles on CX3CR1
Similar Products
Product Notes
The CX3CR1 cx3cr1 (Catalog #AAA1270108) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggatcagt tccctgaatc agtgacagaa aactttgagt acgatgattt ggctgaggcc tgttatattg gggacatcgt ggtctttggg actgtgttcc tgtccatatt ctactccgtc atctttgcca ttggcctggt gggaaatttg ttggtagtgt ttgccctcac caacagcaag aagcccaaga gtgtcaccga catttacctc ctgaacctgg ccttgtctga tctgctgttt gtagccactt tgcccttctg gactcactat ttgataaatg aaaagggcct ccacaatgcc atgtgcaaat tcactaccgc cttcttcttc atcggctttt ttggaagcat attcttcatc accgtcatca gcattgatag gtacctggcc atcgtcctgg ccgccaactc catgaacaac cggaccgtgc agcatggcgt caccatcagc ctaggcgtct gggcagcagc cattttggtg gcagcacccc agttcatgtt cacaaagcag aaagaaaatg aatgccttgg tgactacccc gaggtcctcc aggaaatctg gcccgtgctc cgcaatgtgg aaacaaattt tcttggcttc ctactccccc tgctcattat gagttattgc tacttcagaa tcatccagac gctgttttcc tgcaagaacc acaagaaagc caaagccatt aaactgatcc ttctggtggt catcgtgttt ttcctcttct ggacacccta caacgttatg attttcctgg agacgcttaa gctctatgac ttctttccca gttgtgacat gaggaaggat ctgaggctgg ccctcagtgt gactgagacg gttgcattta gccattgttg cctgaatcct ctcatctatg catttgctgg ggagaagttc agaagatacc tttaccacct gtatgggaaa tgcctggctg tcctgtgtgg gcgctcagtc cacgttgatt tctcctcatc tgaatcacaa aggagcaggc atggaagtgt tctgagcagc aattttactt accacacgag tgatggagat gcattgctcc ttctctga. It is sometimes possible for the material contained within the vial of "CX3CR1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
