CRYBB3 cdna clone
CRYBB3 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B2. Mutations in this gene result in cataract congenital nuclear autosomal recessive type 2. [provided by RefSeq, Feb 2013]
Uniprot Description
CRYBB3: a major structural protein of the eye lens. A member of the beta/gamma-crystallin family.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 22q11.23
Molecular Function: protein binding
Disease: Cataract 22, Multiple Types
Research Articles on CRYBB3
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Product Notes
The CRYBB3 crybb3 (Catalog #AAA1275424) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCGGAAC AGCACGGAGC ACCCGAACAG GCTGCAGCTG GCAAGAGCCA TGGAGACCTT GGGGGCAGCT ACAAGGTGAT CTTGTACGAA CTAGAGAACT TCCAAGGCAA ACGCTGCGAG CTCTCGGCCG AGTGCCCCAG CCTGACCGAC AGCCTGCTGG AGAAGGTGGG CTCCATCCAA GTGGAGTCCG GGCCGTGGCT GGCATTTGAG TCCAGGGCCT TCCGCGGGGA GCAGTTTGTT CTGGAGAAGG GGGATTATCC TCGCTGGGAT GCCTGGTCCA ACAGCCGTGA TAGTGACAGC CTTCTGTCCC TCCAGCCTCT GAATATTGAT AGTCCAGATC ACAAGCTGCA TCTGTTTGAG AACCCAGCTT TCAGTGGCCG CAAGATGGAG ATAGTGGATG ATGACGTGCC CAGCCTGTGG GCTCATGGCT TCCAGGACCG TGTGGCGAGT GTCCGTGCCA TCAACGGGAC GTGGGTTGGC TATGAGTTCC CCGGCTACCG TGGGCGCCAG TACGTGTTTG AGCGGGGCGA GTACCGCCAC TGGAATGAGT GGGACGCCAG CCAGCCGCAG CTGCAGTCTG TGCGCCGCAT CCGTGACCAG AAGTGGCACA AGCGGGGCCG CTTCCCCAGC AGCTGA. It is sometimes possible for the material contained within the vial of "CRYBB3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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