CHP cdna clone
CHP cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. [provided by RefSeq, Jul 2008]
Uniprot Description
CHP: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate- phosphorylations in a calcium-dependent manner. Belongs to the calcineurin regulatory subunit family. CHP subfamily.
Protein type: Calcium-binding
Chromosomal Location of Human Ortholog: 15q13.3
Cellular Component: cytoplasm; endoplasmic reticulum; focal adhesion; Golgi membrane; microtubule cytoskeleton; nucleus; plasma membrane; transport vesicle
Molecular Function: calcium ion binding; calcium-dependent protein binding; kinase binding; microtubule binding; potassium channel regulator activity; protein binding; transporter activity
Biological Process: cytoplasmic microtubule organization and biogenesis; hyaluronan catabolic process; inhibition of NF-kappaB transcription factor; membrane docking; microtubule bundle formation; negative regulation of protein amino acid autophosphorylation; negative regulation of protein amino acid phosphorylation; negative regulation of protein import into nucleus; negative regulation of protein kinase activity; negative regulation of protein ubiquitination; positive regulation of protein amino acid glycosylation; positive regulation of protein transport; positive regulation of sodium:hydrogen antiporter activity; potassium ion transport; protein export from nucleus; protein stabilization; regulation of intracellular pH; small GTPase mediated signal transduction
Research Articles on CHP
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Product Notes
The CHP chp1 (Catalog #AAA1276529) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggagtctc actctgtcac ccaggctgga gtgcagtggc gtgatcttgg ctcactgcaa cctctgcctc ctgggttcaa gcaattctcc cacctcagcc tcccaagtag ctgggattac agacgtgtgc caccatacct gggtaatttt tgcattttta gtggagaggg agtttcacca tgttggccag gttggtcttg a. It is sometimes possible for the material contained within the vial of "CHP, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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