CFHR5 cdna clone
CFHR5 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). [provided by RefSeq, Jan 2010]
Uniprot Description
CFHR5: Involved in complement regulation. Defects in CFHR5 have been found in patients with atypical hemolytic uremic syndrome and may contribute to the disease. Atypical hemolytic uremic syndrome is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q31.3
Disease: Cfhr5 Deficiency
Research Articles on CFHR5
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Product Notes
The CFHR5 cfhr5 (Catalog #AAA1272331) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGTTGCTCT TATTCAGTGT AATCCTAATC TCATGGGTAT CCACTGTTGG GGGAGAAGGA ACACTTTGTG ATTTTCCAAA AATACACCAT GGATTTCTGT ATGATGAAGA AGATTATAAC CCTTTTTCCC AAGTTCCTAC AGGGGAAGTT TTCTATTACT CCTGTGAATA TAATTTTGTG TCTCCTTCAA AATCCTTTTG GACTCGCATA ACATGCACAG AAGAAGGATG GTCACCAACA CCGAAGTGTC TCAGAATGTG TTCCTTTCCT TTTGTGAAAA ATGGTCATTC TGAATCTTCA GGACTAATAC ATCTGGAAGG TGATACTGTA CAAATTATTT GCAACACAGG ATACAGCCTT CAAAACAATG AGAAAAACAT TTCGTGTGTA GAACGGGGCT GGTCCACTCC TCCCATATGC AGCTTCACTA AAGGAGAATG TCATGTTCCA ATTTTAGAAG CCAATGTAGA TGCTCAGCCA AAAAAAGAAA GCTACAAAGT TGGAGACGTG TTGAAATTCT CCTGCAGAAA AAATCTTATA AGAGTTGGAT CAGACTCAGT TCAATGTTAC CAATTTGGGT GGTCACCTAA CTTTCCAACA TGCAAAGGAC AAGTACGATC ATGTGGTCCA CCTCCTCAAC TCTCCAATGG TGAAGTTAAG GAGATAAGAA AAGAGGAATA TGGACACAAT GAAGTAGTGG AATATGATTG CAATCCTAAT TTTATAATAA ACGGGCCTAA GAAAATACAA TGTGTGGATG GAGAATGGAC AACTTTACCC ACTTGTGTTG AACAAGTGAA AACATGTGGA TACATACCTG AACTCGAGTA CGGTTATGTT CAGCCGTCTG TCCCTCCCTA TCAACATGGA GTTTCAGTCG AGGTGAATTG CAGAAATGAA TATGCAATGA TTGGAAATAA CATGATTACC TGTATTAATG GAATATGGAC AGAGCTTCCT ATGTGTGTTG CAACACACCA ACTTAAGAGG TGCAAAATAG CAGGAGTTAA TATAAAAACA TTACTCAAGC TATCTGGGAA AGAATTTAAT CATAATTCTA GAATACGTTA CAGATGTTCA GACATCTTCA GATACAGGCA CTCAGTCTGT ATAAACGGGA AATGGAATCC TGAAGTAGAC TGCACAGAAA AAAGGGAACA ATTCTGCCCA CCGCCACCTC AGATACCTAA TGCTCAGAAT ATGACAACCA CAGTGAATTA TCAGGATGGA GAAAAAGTAG CTGTTCTCTG TAAAGAAAAC TATCTACTTC CAGAAGCAAA AGAAATTGTA TGTAAAGATG GACGATGGCA ATCATTACCA CGCTGTGTTG AGTCTACTGC ATATTGTGGG CCCCCTCCAT CTATTAACAA TGGAGATACC ACCTCATTCC CATTATCAGT ATATCCTCCA GGGTCAACAG TGACGTACCG TTGCCAGTCC TTCTATAAAC TCCAGGGCTC TGTAACTGTA ACATGCAGAA ATAAACAGTG GTCAGAACCA CCAAGATGCC TAGATCCATG TGTGGTATCT GAAGAAAACA TGAACAAAAA TAACATACAG TTAAAATGGA GAAACGATGG AAAACTCTAT GCAAAAACAG GGGATGCTGT TGAATTCCAG TGTAAATTCC CACATAAAGC GATGATATCA TCACCACCAT TTCGAGCAAT CTGTCAGGAA GGGAAATTTG AATATCCTAT ATGTGAATGA. It is sometimes possible for the material contained within the vial of "CFHR5, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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