CDK4 cdna clone
CDK4 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
Uniprot Description
CDK4: a protein kinase of the CDK family that is important for cell cycle G1 phase progression. Its activity is restricted to the G1-S phase. Controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). Phosphorylates the retinoblastoma gene product (Rb). Point mutations found in somatic and familial melanoma. Amplified in sarcomas, glioma and lymphoma. Amplified, methylated or deleted in head and neck squamous cell carcinoma. Overexpression drives epithelial tumors in mice. Disruption makes mice resistant to cancer. Inhibitor: PD332991.
Protein type: Protein kinase, CMGC; Cell cycle regulation; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.22; CMGC group; CDK family; CDK/CDK4 subfamily; CDK4 subfamily
Chromosomal Location of Human Ortholog: 12q14
Cellular Component: chromatin; cyclin-dependent protein kinase holoenzyme complex; cytosol; nuclear membrane; nucleolus; nucleoplasm; nucleus
Molecular Function: cyclin binding; cyclin-dependent protein kinase activity; cyclin-dependent protein kinase regulator activity; protein binding
Biological Process: G1/S transition of mitotic cell cycle; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of fibroblast proliferation; protein amino acid phosphorylation; regulation of gene expression; response to drug
Disease: Melanoma, Cutaneous Malignant, Susceptibility To, 3
Research Articles on CDK4
Similar Products
Product Notes
The CDK4 cdk4 (Catalog #AAA1272081) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggctacct ctcgatatga gccagtggct gaaattggtg tcggtgccta tgggacagtg tacaaggccc gtgatcccca cagtggccac tttgtggccc tcaagagtgt gagagtcccc aatggaggag gaggtggagg aggccttccc atcagcacag ttcgtgaggt ggctttactg aggcgactgg aggcttttga gcatcccaat gttgtccggc tgatggacgt ctgtgccaca tcccgaactg accgggagat caaggtaacc ctggtgtttg agcatgtaga ccaggaccta aggacatatc tggacaaggc acccccacca ggcttgccag ccgaaacgat caaggatctg atgcgccagt ttctaagagg cctagatttc cttcatgcca attgcatcgt tcaccgagat ctgaagccag agaacattct ggtgacaagt ggtggaacag tcaagctggc tgactttggc ctggccagaa tctacagcta ccagatggca cttacacccg tggttgttac actctggtac cgagctcccg aagttcttct gcagtccaca tatgcaacac ctgtggacat gtggagtgtt ggctgtatct ttgcagagat gtttcgtcga aagcctctct tctgtggaaa ctctgaagcc gaccagttgg gcaaaatctt tgacctgatt gggctgcctc cagaggatga ctggcctcga gatgtatccc tgccccgtgg agcctttccc cccagagggc cccgcccagt gcagtcggtg gtacctgaga tggaggagtc gggagcacag ctgctgctgg aaatgctgac ttttaaccca cacaagcgaa tctctgcctt tcgagctctg cagcactctt atctacataa ggatgaaggt aatccggagt ga. It is sometimes possible for the material contained within the vial of "CDK4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
