CDC7 cdna clone
CDC7 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]
Uniprot Description
CDC7: an evolutionarily conserved serine/threonine protein kinase of the CDC7 family. Predominantly localized in the nucleus, it plays a pivotal role in linking cell cycle regulation to genome duplication, being essential for the firing of DNA replication origins. Plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex. The human protein requires phosphorylation by CDK1 at T376 and binding to activator of S-phase kinase (ASK)/DBF4B to be fully activated. The interaction between Cdc7 and DBFK subunits facilitates ATP binding and substrate recognition by the Cdc7 kinase. Although CDC7 expression levels appear to be constant throughout the cell cycle, the expression levels of DBF4B is cell cycle-regulated. Thus, the CDC7 activity is activated during S phase in eukaryotes. The Cdc7/ DBF4B complex regulates initiation of DNA replication by phosphorylating chromatin-bound mini-chromosome maintenance protein 2 (MCM2). Impaired Cdc7 kinase activity leads to S-phase arrest. Plays a role in the TGF-beta regulation of smooth muscle cell (SMC) differentiation. Interacts with Smad3 to facilitate Smad3 binding to SMC marker promoter, leading to the activation of SMC marker gene transcription.
Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Kinase, protein; Other group; CDC7 family
Chromosomal Location of Human Ortholog: 1p22
Cellular Component: cytoplasm; intercellular bridge; microtubule cytoskeleton; nucleoplasm; nucleus
Molecular Function: kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: DNA replication; DNA replication initiation; double-strand break repair via break-induced replication; G1/S transition of mitotic cell cycle; peptidyl-serine phosphorylation; phagocytosis; positive regulation of cell proliferation; regulation of cell shape
Research Articles on CDC7
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Product Notes
The CDC7 cdc7 (Catalog #AAA1269204) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGAGGCGT CTTTGGGGAT TCAGATGGAT GAGCCAATGG CTTTTTCTCC CCAGCGTGAC CGGTTTCAGG CTGAAGGCTC TTTAAAAAAA AACGAGCAGA ATTTTAAACT TGCAGGTGTT AAAAAAGATA TTGAGAAGCT TTATGAAGCT GTACCACAGC TTAGTAATGT GTTTAAGATT GAGGACAAAA TTGGAGAAGG CACTTTCAGC TCTGTTTATT TGGCCACAGC ACAGTTACAA GTAGGACCTG AAGAGAAAAT TGCTCTAAAA CACTTGATTC CAACAAGTCA TCCTATAAGA ATTGCAGCTG AACTTCAGTG CCTAACAGTG GCTGGGGGGC AAGATAATGT CATGGGAGTT AAATACTGCT TTAGGAAGAA TGATCATGTA GTTATTGCTA TGCCATATCT GGAGCATGAG TCGTTTTTGG ACATTCTGAA TTCTCTTTCC TTTCAAGAAG TACGGGAATA TATGCTTAAT CTGTTCAAAG CTTTGAAACG CATTCATCAG TTTGGTATTG TTCACCGTGA TGTTAAGCCC AGCAATTTTT TATATAATAG GCGCCTGAAA AAGTATGCCT TGGTAGACTT TGGTTTGGCC CAAGGAACCC ATGATACGAA AATAGAGCTT CTTAAATTTG TCCAGTCTGA AGCTCAGCAG GAAAGGTGTT CACAAAACAA ATCCCACATA ATCACAGGAA ACAAGATTCC ACTGAGTGGC CCAGTACCTA AGGAGCTGGA TCAGCAGTCC ACCACAAAAG CTTCTGTTAA AAGACCCTAC ACAAATGCAC AAATTCAGAT TAAACAAGGA AAAGACGGAA AGGAGGGATC TGTAGGCCTT TCTGTCCAGC GCTCTGTTTT TGGAGAAAGA AATTTCAATA TACACAGCTC CATTTCACAT GAGAGCCCTG CAGTGAAACT CATGAAGCAG TCAAAGACTG TGGATGTACT GTCTAGAAAG TTAGCAACAA AAAAGAAGGC TATTTCTACG AAAGTTATGA ATAGTGCTGT GATGAGGAAA ACTGCCAGTT CTTGCCCAGC TAGCCTGACC TGTGACTGCT ATGCAACAGA TAAAGTTTGT AGTATTTGCC TTTCAAGGCG TCAGCAGGTT GCCCCTAGGG CAGGTACACC AGGATTCAGA GCACCAGAGG TCTTGACAAA GTGCCCCAAT CAAACTACAG CAATTGACAT GTGGTCTGCA GGTGTCATAT TTCTTTCTTT GCTTAGTGGA CGATATCCAT TTTATAAAGC AAGTGATGAT TTAACTGCTT TGGCCCAAAT TATGACAATT AGGGGATCCA GAGAAACTAT CCAAGCTGCT AAAACTTTTG GGAAATCAAT ATTATGTAGC AAAGAAGTTC CAGCACAAGA CTTGAGAAAA CTCTGTGAGA GACTCAGGGG TATGGATTCT AGCACTCCCA AGTTAACAAG TGATATACAA GGGCATGCTT CTCATCAACC AGCTATTTCA GAGAAGACTG ACCATAAAGC TTCTTGCCTC GTTCAAACAC CTCCAGGACA ATACTCAGGG AATTCATTTA AAAAGGGGGA TAGTAATAGC TGTGAGCATT GTTTTGATGA GTATAATACC AATTTAGAAG GCTGGAATGA GGTACCTGAT GAAGCTTATG ACCTGCTTGA TAAACTTCTA GATCTAAATC CAGCTTCAAG AATAACAGCA GAAGAAGCTT TGTTGCATCC ATTTTTTAAA GATATGAGCT TGTGA. It is sometimes possible for the material contained within the vial of "CDC7, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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