CCNC cdna clone
CCNC cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
CCNC: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Belongs to the cyclin family. Cyclin C subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: cyclin-dependent protein kinase holoenzyme complex; nucleoplasm; nucleus
Molecular Function: cyclin-dependent protein kinase regulator activity; protein binding; protein serine/threonine kinase activity
Biological Process: positive regulation of cyclin-dependent protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter
Research Articles on CCNC
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Product Notes
The CCNC ccnc (Catalog #AAA1272334) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcaggga acttttggca gagctcccac tatttgcaat ggattttgga taaacaagat ctgttgaagg agcgccaaaa ggatttaaag tttctctcag aggaagaata ttggaagtta caaatatttt ttacaaatgt tatccaagca ttaggtgaac atcttaaatt aagacaacaa gttattgcca ctgctacggt atatttcaag agattctatg ccaggtattc tctgaaaagt atagatcctg tattaatggc tcctacatgt gtgtttttgg catccaaagt agaggaattt ggagtagttt caaatacaag attgattgct gctgctactt ctgtattaaa aactagattt tcatatgcct ttccaaagga atttccttat aggatgaatc atatattaga atgtgaattc tatttgttag aactaatgga ttgttgcttg atagtgtatc atccttatag acctttgctc cagtatgtgc aggacatggg ccaagaagac atgttgcttc cccttgcatg gaggatagtg aatgatacct acagaacgga tctttgccta ctgtatcctc ctttcatgat agctttagct tgcctacatg tagcctgtgt tgtacagcag aaagatgcca ggcaatggtt tgctgagctt tctgtggata tggaaaagat tttggaaata atcagggtta ttttaaaact atatgagcag tggaagaatt tcgatgagag aaaagagatg gcaaccattc ttagtaagat gccaaaacca aaaccacctc caaacagtga aggagagcag ggtccaaatg gaagtcagaa ctctagctac agccaatctt aa. It is sometimes possible for the material contained within the vial of "CCNC, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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