BAP1 cdna clone
BAP1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]
Uniprot Description
BAP1: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'- linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Acts as a tumor suppressor. Component of the PR-DUB complex, at least composed of BAP1 and ASXL1. Interacts with BRCA1 (via the RING finger). Interacts (via HBM-like motif) with HCFC1. Highly expressed in testis, placenta and ovary. Expressed in breast. Belongs to the peptidase C12 family. BAP1 subfamily.
Protein type: Tumor suppressor; Ubiquitin conjugating system; Protease; Ubiquitin-specific protease; EC 3.4.19.12
Chromosomal Location of Human Ortholog: 3p21.1
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: chromatin binding; protein binding; ubiquitin-specific protease activity
Biological Process: negative regulation of cell proliferation; protein deubiquitination; regulation of cell cycle; regulation of cell growth
Disease: Tumor Predisposition Syndrome
Research Articles on BAP1
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Product Notes
The BAP1 bap1 (Catalog #AAA1267614) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgaataagg gctggctgga gctggagagc gacccaggcc tcttcaccct gctcgtggaa gatttcggtg tcaagggggt gcaagtggag gagatctacg accttcagag caaatgtcag ggccctgtat atggatttat cttcctgttc aaatggatcg aagagcgccg gtcccggcga aaggtctcta ccttggtgga tgatacgtcc gtgattgatg atgatattgt gaataacatg ttctttgccc accagctgat acccaactct tgtgcaactc atgccttgct gagcgtgctc ctgaactgca gcagcgtgga cctgggaccc accctgagtc gcatgaagga cttcaccaag ggttttagcc ctgagagcaa aggatatgcg attggcaatg ccccggagtt ggccaaggcc cataatagcc atgccaggcc cgagccacgc cacctccctg agaagcagaa tggccttagt gcagtgcgga ccatggaggc gttccacttt gtcagctatg tgcctatcac aggccggctc tttgagctgg atgggctgaa ggtctacccc attgaccatg ggccctgggg ggaggacgag gagtggacag acaaggcccg gcgggtcatc atggagcgta tcggcctcgc cactgcaggg gagccctacc acgacatccg cttcaacctg atggcagtgg tgcccgaccg caggatcaag tatgaggcca ggctgcatgt gctgaaggtg aaccgtcaga cagtactaga ggctctgcag cagctgataa gagtaacaca gccagagctg attcagaccc acaagtctca agagtcacag ctgcctgagg agtccaagtc agccagcaac aagtccccgc tggtgctgga agcaaacagg gcccctgcag cctctgaggg caaccacaca gatggtgcag aggaggcggc tggttcatgc gcacaagccc catcccacag ccctcccaac aaacccaagc tagtggtgaa gcctccaggc agcagcctca atggggttca ccccaacccc actcccattg tccagcggct gccggccttt ctagacaatc acaattatgc caagtccccc atgcaggagg aagaagacct ggcggcaggt gtgggccgca gccgagttcc agtccgccca ccccagcagt actcagatga tgaggatgac tatgaggatg acgaggagga tgacgtgcag aacaccaact ctgcccttag gtataagggg aagggaacag ggaagccagg ggcattgagc ggttctgctg atgggcaact gtcagtgctg cagcccaaca ccatcaacgt cttggctgag aagctcaaag agtcccagaa ggacctctca attcctctgt ccatcaagac tagcagcggg gctgggagtc cggctgtggc agtgcccaca cactcgcagc cctcacccac ccccagcaat gagagtacag acacggcctc tgagatcggc agtgctttca actcgccact gcgctcgcct atccgctcag ccaacccgac gcggccctcc agccctgtca cctcccacat ctccaaggtg ctttttggag aggatgacag cctgctgcgt gttgactgca tacgctacaa ccgtgctgtc cgtgatctgg gtcctgtcat cagcacaggc ctgctgcacc tggctgagga tggggtgctg agtcccctgg cgctgacaga gggtgggaag ggttcctcgc cctccatcag accaatccaa ggcagccagg ggtccagcag cccagtggag aaggaggtcg tggaagccac ggacagcaga gagaagacgg ggatggtgag gcctggcgag cccttgagtg gggagaaata ctcacccaag gagctgctgg cactgctgaa gtgtgtggag gctgagattg caaactatga ggcgtgcctc aaggaggagg tagagaagag gaagaagttc aagattgatg accagagaag gacccacaac tacgatgagt tcatctgcac ctttatctcc atgctggctc aggaaggcat gctggccaac ctagtggagc agaacatctc cgtgcggcgg cgccaagggg tcagcatcgg ccggctccac aagcagcgga agcctgaccg gcggaaacgc tctcgcccct acaaggccaa gcgccagtga. It is sometimes possible for the material contained within the vial of "BAP1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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