ATIC cdna clone
ATIC cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009]
Uniprot Description
ATIC: Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis. Defects in ATIC are the cause of AICAR transformylase/IMP cyclohydrolase deficiency (AICAR). A neurologically devastating inborn error of purine biosynthesis. Patients excrete massive amounts of AICA-riboside in the urine and accumulate AICA- ribotide and its derivatives in erythrocytes and fibroblasts. AICAR causes profound mental retardation, epilepsy, dysmorphic features and congenital blindness. Belongs to the PurH family.
Protein type: Nucleotide Metabolism - purine; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.2.3; Hydrolase; EC 3.5.4.10; Mitochondrial; Methyltransferase
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: cell-cell adherens junction; cytosol; membrane
Molecular Function: IMP cyclohydrolase activity; phosphoribosylaminoimidazolecarboxamide formyltransferase activity; protein homodimerization activity
Biological Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; purine ribonucleoside monophosphate biosynthetic process
Disease: Aicar Transformylase/imp Cyclohydrolase Deficiency
Research Articles on ATIC
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Product Notes
The ATIC atic (Catalog #AAA1273407) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggctcccg gccagctcgc cttatttagt gtctctgaca aaaccggcct tgtggaattt gcaagaaacc tgaccgctct tggtttgaat ctggtcgctt ccggagggac tgcaaaagct ctcagggatg ctggtctggc agtcagagat gtctctgagt tgacgggatt tcctgaaatg ttggggggac gtgtgaaaac tttgcatcct gcagtccatg ctggaatcct agctcgtaat attccagaag ataatgctga catggccaga cttgatttca atcttataag agttgttgcc tgcaatctct atccctttgt aaagacagtg gcttctccag gtgtaactgt tgaggaggct gtggagcaaa ttgacattgg tggagtaacc ttactgagag ctgcagccaa aaaccacgct cgagtgacag tggtgtgtga accagaggac tatgtggtgg tgtccacgga gatgcagagc tccgagagta aggacacctc cttggagact agacgccagt tagccttgaa ggcattcact catacggcac aatatgatga agcaatttca gattatttca ggaaacagta cagcaaaggc gtatctcaga tgcccttgag atatggaatg aacccacatc agacccctgc ccagctgtac acactgcagc ccaagcttcc catcacagtt ctaaatggag cccctggatt tataaacttg tgcgatgctt tgaacgcctg gcagctggtg aaggaactca aggaggcttt aggtattcca gccgctgcct ctttcaaaca tgtcagccca gcaggtgctg ctgttggaat tccactcagt gaagatgagg ccaaagtctg catggtttat gatctctata aaaccctcac acccatctca gcggcatatg caagagcaag aggggctgat aggatgtctt catttggtga ttttgttgca ttgtccgatg tttgtgatgt accaactgca aaaattattt ccagagaagt atctgatggt ataattgccc caggatatga agaagaagcc ttgacaatac tttccaaaaa gaaaaatgga aactattgtg tccttcagat ggaccaatct tacaaaccag atgaaaatga agttcgaact ctctttggtc ttcatttaag ccagaagaga aataatggtg tcgtcgacaa gtcattattt agcaatgttg ttaccaaaaa taaagatttg ccagagtctg ccctccgaga cctcatcgta gccaccattg ctgtcaagta cactcagtct aactctgtgt gctacgccaa gaacgggcag gttatcggca ttggagcagg acagcagtct cgtatacact gcactcgcct tgcaggagat aaggcaaact attggtggct tagacaccat ccacaagtgc tttcgatgaa gtttaaaaca ggagtgaaga gagcagaaat ctccaatgcc atcgatcaat atgtgactgg aaccattggc gaggatgaag atttgataaa gtggaaggca ctgtttgagg aagtccctga gttactcact gaggcagaga agaaggaatg ggttgagaaa ctgactgaag tttctatcag ctctgatgcc ttcttccctt tccgagataa cgtagacaga gctaaaagga gtggtgtggc gtacattgcg gctccctccg gttctgctgc tgacaaagtt gtgattgagg cctgcgacga actgggaatc atcctcgctc atacgaacct tcggctcttc caccactga. It is sometimes possible for the material contained within the vial of "ATIC, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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