ARHGEF3 cdna clone
ARHGEF3 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
ARHGEF3: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs; Motility/polarity/chemotaxis; GAPs, Rac/Rho
Chromosomal Location of Human Ortholog: 3p14.3
Cellular Component: cytosol; intracellular
Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity
Biological Process: positive regulation of apoptosis; regulation of small GTPase mediated signal transduction; Rho protein signal transduction
Research Articles on ARHGEF3
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Product Notes
The ARHGEF3 arhgef3 (Catalog #AAA1272158) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGAAGCTCC CTTGCCTCAG CTCCTATGAT AGCTACTGCA GCAATCAAGT AGCCGCCAAA GCTCTGCTGG ACCACAAAAA GCAAGATCAC CGAGTCCAGG ATTTCCTACA GCGATGTTTA GAATCCCCCT TTAGCCGCAA ACTAGATCTC TGGAATTTCC TCGATATTCC AAGAAGCCGC CTGGTAAAAT ACCCTCTGCT TCTCCGAGAA ATCTTGAGGC ACACACCAAA TGATAATCCA GATCAGCAGC ACTTGGAAGA AGCTATAAAT ATCATTCAGG GAATTGTGGC AGAAATCAAC ACCAAGACTG GTGAATCTGA ATGCCGCTAT TATAAAGAGC GGCTTCTTTA CTTGGAAGAA GGCCAGAAAG ACTCCCTGAT CGACAGCTCT CGAGTCGTGT GTTGTCATGG TGAACTGAAG AACAATCGGG GCGTGAAACT GCATGTTTTC CTGTTCCAAG AAGTGCTTGT GATCACTCGA GCCGTCACCC ACAATGAGCA GCTTTGCTAC CAGCTGTACC GTCAGCCAAT CCCCGTGAAA GACCTCCTGC TGGAAGACCT CCAGGATGGA GAAGTGAGGC TGGGTGGCTC CCTGCGAGGG GCATTCAGCA ACAATGAGAG AATTAAAAAC TTCTTCAGAG TCAGTTTCAA AAATGGATCC CAAAGTCAGA CCCACTCGCT ACAAGCCAAT GACACTTTCA ACAAACAGCA GTGGCTTAAC TGTATTCGTC AAGCCAAAGA AACAGTTTTG TGTGCTGCCG GGCAAGCTGG GGTGCTTGAC TCCGAGGGAT CGTTCCTAAA TCCCACCACC GGGAGCAGAG AGCTACAGGG AGAAACAAAA CTTGAGCAGA TGGACCAATC GGACAGTGAG TCAGACTGTA GTATGGACAC GAGTGAGGTC AGCCTCGACT GTGAGCGCAT GGAACAGACA GACTCTTCCT GTGGAAACAG CAGGCACGGT GAAAGTAACG TCTGA. It is sometimes possible for the material contained within the vial of "ARHGEF3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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