ARHGEF10 cdna clone
ARHGEF10 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Uniprot Description
ARHGEF10: May play a role in developmental myelination of peripheral nerves. Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV). Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs; GEFs, Rac/Rho
Chromosomal Location of Human Ortholog: 8p23
Cellular Component: centrosome
Molecular Function: kinesin binding; protein binding; Rho guanyl-nucleotide exchange factor activity
Biological Process: centrosome duplication; myelination in the peripheral nervous system; positive regulation of stress fiber formation
Disease: Slowed Nerve Conduction Velocity, Autosomal Dominant
Research Articles on ARHGEF10
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Product Notes
The ARHGEF10 arhgef10 (Catalog #AAA1268950) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggagaatc cagaagaagc aatttacgat gacgttccaa gggaaaactc agactctgaa ccagatgaaa tgatttatga tgatgttgag aatggggatg aaggtggaaa cagctccttg gaatacggat ggagttcgag tgaatttgaa agttacgaag agcagagtga ctcggagtgc aagaatggga ttcccaggtc cttcctgcgc agcaaccaca aaaagcaaat gcagaagctc gtgaaggccg cgaaggacgg caccaaggac gggctggaga ggaccagggc agccgtgaag aggggccgct ccttcatcag gaccaagtct ctcatcgcac aggatcacag atcttctctt gaggaagaac agaatttgtt cattgatgtt gactgcaagc acccggaagc catcttgacc ccgatgcccg agggtttatc tcagcagcag gttgtaagaa gatatatact gggttcagtt gtcgacagtg aaaagaacta cgtagatgct cttaagagga ttttggagca atatgagaag ccgctgtctg agatggagcc aaaggttctg agtgagagga agctgaagac ggtgttctac cgagtcaaag agatcctgca gtgccactcg ctatttcaga tcgcgctggc cagccgcgtt tccgagtggg actccgtgga aatgataggc gttgtcttcg tggcttcgtt ttctaagtcc atggtgctgg atgcatacag tgaatatgtg aacaatttca gcacagccgt ggcagtcctc aagaaaacat gtgccacaaa gcccgctttt cttgaatttt taaagcagga acaggaggcc agccccgatc gaaccacgct ctacagcctg atgatgaagc ccatccagag gttcccacag ttcatcctcc tgctccagga catgctgaag aacacctcca aaggccaccc cgacaggctg cctcttcaga tggccctgac agagctcgaa acactagcag agaagttaaa tgaaagaaag agagatgctg atcaacgctg tgaagtgaag caaatagcca aagccataaa cgaaagatac ctgaacaagg ttgagagagg ttttcttcaa ctctattcca aaattatttt tgctttgtgc taa. It is sometimes possible for the material contained within the vial of "ARHGEF10, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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