APOBEC3F cdna clone
APOBEC3F cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Description
APOBEC3F: Host cellular restriction factor that may have antiviral activities against exogenous and endogenous viruses, as well as retrotransposons. After being packaged into HIV-1 virions, blocks productive infection by massively editing dC residues to dU on the DNA minus strand during reverse transcription. The editing of the minus strand DNA of HIV-1 during reverse transcription leads to G- to-A transitions in the plus strand. The inhibition of viral replication is either due to the degradation of the minus strand before its integration or to the lethality of the hypermutations. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. Belongs to the cytidine and deoxycytidylate deaminase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA processing; EC 3.5.4.-; Hydrolase
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: apolipoprotein B mRNA editing enzyme complex; cytoplasm; ribonucleoprotein complex
Molecular Function: cytidine deaminase activity; protein binding; RNA binding; zinc ion binding
Biological Process: base conversion or substitution editing; defense response to virus; innate immune response; negative regulation of retroviral genome replication; negative regulation of viral genome replication; negative regulation of viral reproduction; positive regulation of defense response to virus by host
Research Articles on APOBEC3F
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Product Notes
The APOBEC3F apobec3f (Catalog #AAA1276901) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgaagcctc acttcagaaa cacagtggag cgaatgtatc gagacacatt ctcctacaac ttttataata gacccatcct ttctcgtcgg aataccgtct ggctgtgcta cgaagtgaaa acaaagggtc cctcaaggcc ccgtttggac gcaaagatct ttcgaggcca ggtgtattcc cagcctgagc accacgcaga aatgtgcttc ctctcttggt tctgtggcaa ccagctgcct gcttacaagt gtttccagat cacctggttt gtatcctgga ccccctgccc ggactgtgtg gcgaagctgg ccgaattcct gtctgagcac cccaatgtca ccctgaccat ctccgccgcc cgcctctact actactggga aagagattac cgaagggcgc tctgcaggct gagtcaggca ggggcccgtg tgaagattat ggacgatgaa gaatttgcat actgctggga aaactttgtg tacagtgaag gtcagccatt catgccttgg tacaaattcg atgacaatta tgcattcctg caccgcacgc taaaggagat tctcagaaac ccgatggagg caatgtatcc acacatattc tacttccact ttaaaaacct acgcaaagcc tatggtcgga acgaaagctg gctgtgcttc accatggaag ttgtaaagca ccactcacct atctcctgga agaggggcgt cttccgaaac caggtggatc ctgagaccca ttgtcatgca gaaaggtgct tcctctcttg gttctgtgac gacatactgt ctcctaacac aaactacgag gtcacctggt acacatcttg gagcccttgc ccagagtgtg caggggaggt ggccgagttc ctggccaggc acagcaacgt gaatctcacc atcttcaccg cccgcctcta ctacttctgg gatacagatt accaggaggg gctccgcagc ctgagtcagg aaggggcctc cgtggagatc atgggctaca aagattttaa atattgttgg gaaaactttg tgtacaatga tgatgagcca ttcaagcctt ggaaaggact aaaatacaac tttctattcc tggacagcaa gctgcaggag attctcgagt ga. It is sometimes possible for the material contained within the vial of "APOBEC3F, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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