ALG3 cdna clone
ALG3 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with congenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Uniprot Description
ALG3: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in ALG3 are the cause of congenital disorder of glycosylation type 1D (CDG1D); also known as carbohydrate-deficient glycoprotein syndrome type IV (CDGS4). CDGs are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under-glycosylated serum glycoproteins. Belongs to the glycosyltransferase 58 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Endoplasmic reticulum; Transferase; Membrane protein, integral; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, multi-pass; EC 2.4.1.258
Chromosomal Location of Human Ortholog: 3q27.1
Cellular Component: endoplasmic reticulum membrane
Molecular Function: alpha-1,3-mannosyltransferase activity
Biological Process: dolichol-linked oligosaccharide biosynthetic process
Disease: Congenital Disorder Of Glycosylation, Type Id
Research Articles on ALG3
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Product Notes
The ALG3 alg3 (Catalog #AAA1265912) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcggctg ggctgcggaa acgcggccgg tccggttccg cggcccaggc agagggactc tgcaagcaat ggctgcagcg cgcctggcaa gagcggcgcc tgctgctgcg ggagccgcgc tacacgctgc tggtggccgc ctgcctctgc ctggcggagg tgggcatcac cttctgggtc attcacaggg tggcatacac agagattgac tggaaggcct acatggccga ggtagaaggc gtcatcaatg gtacctatga ctatacccaa ctgcagggtg acaccggacc acttgtgtac ccagctggtt tcgtgtacat ctttatgggg ttgtactatg ccaccagccg aggcactgac atccgcatgg cccagaacat ctttgctgtg ctctacctgg ctaccttgct gcttgtcttc ttgatctatc accagacctg caaggtacct cccttcgtct ttttcttcat gtgctgcgcc tcttaccgtg tccactccat ctttgtgctg cggctcttca atgacccagt ggccatggtg ctgctcttcc tcagtatcaa cctcctgctg gcccagcgct ggggctgggg ttgctgcttt ttcagcctgg cagtctctgt gaagatgaat gtgctgctct tcgcccctgg gttactgttt cttctcctca cacagtttgg cttccgtggg gccctcccca agctgggaat ctgtgctggc cttcaggtgg tgctggggct gcccttcctg ctggagaacc ccagcggcta cctgtcccgc tcctttgacc ttggccgcca gtttctgttc cactggacag tgaactggcg cttcctccca gaggcgctct tcctgcatcg agccttccac ctggccctgt tgactgccca cctcaccctg ctcctgctgt ttgccctctg caggtggcac aggacagggg aaagtatctt gtcgctgctg agggatccct ccaaaaggaa ggttccaccc cagcccctta cacccaacca gatcgtttct accctcttca cctccaactt cattggcatc tgcttcagcc gctccctcca ctaccagttc tacgtctggt atttccacac actgccctac ctcctgtggg ccatgcctgc acgctggctc acacacctgc tcaggttgtt ggtgctgggg ctcatcgagc tctcctggaa cacataccct tccacatcct gcagctctgc tgccctgcac atatgccatg ccgtcatcct gctgcagctc tggctgggcc cgcagccttt ccccaagagc acccaacaca gcaagaaagc ccactga. It is sometimes possible for the material contained within the vial of "ALG3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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