AGBL5 cdna clone
AGBL5 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a metallocarboxypeptidase involved in protein deglutamylation and a member of the peptidase M14 family of proteins. The encoded protein has been described as a "dual-functional" deglutamylase that can remove glutamate residues from both carboxyl termini and side chains of protein substrates. This deglutamylase activity may be important in antiviral immunity. Mutations in this gene are associated with retinitis pigmentosa. [provided by RefSeq, Jul 2016]
Uniprot Description
AGBL5: Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post- translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/ CCP1, AGBL1/CCP4 and AGBL4/CCP6. Belongs to the peptidase M14 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.17.-; Protease
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component: cytoplasm; cytosol; midbody; nucleus
Molecular Function: metallocarboxypeptidase activity; tubulin binding
Biological Process: defense response to virus
Disease: Retinitis Pigmentosa 75
Research Articles on AGBL5
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Product Notes
The AGBL5 agbl5 (Catalog #AAA1270696) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGAGCTGC GCTGTGGGGG ATTGCTGTTC AGTTCTCGCT TTGATTCAGG GAATCTAGCC CACGTGGAGA AGGTGGAATC TTTGTCCAGT GATGGGGAAG GGGTAGGAGG TGGGGCGTCA GCCCTGACCA GTGGCATTGC CTCTTCCCCT GACTATGAAT TCAACGTGTG GACCCGACCA GACTGTGCTG AAACGGAATT TGAGAATGGG AACAGGTCAT GGTTCTACTT CAGCGTCCGG GGAGGAATGC CAGGAAAACT CATCAAGATC AACATTATGA ACATGAACAA GCAGAGCAAG CTGTATTCCC AGGGCATGGC CCCCTTTGTG CGCACACTGC CCACCCGGCC ACGCTGGGAA CGCATTCGAG ACCGGCCCAC CTTTGAGATG ACAGAGACGC AGTTTGTGTT ATCCTTTGTT CATCGTTTCG TGGAGGGCCG TGGGGCCACC ACCTTCTTCG CCTTCTGCTA CCCCTTCTCC TACAGTGACT GCCAGGAACT GCTAAACCAG CTAGACCAGC GCTTTCCGGA GAACCACCCT ACCCATAGCA GCCCCCTGGA TACCATCTAT TACCATCGGG AGCTCCTTTG CTATTCTCTG GATGGACTTC GTGTAGATCT GCTGACGATC ACTTCCTGCC ATGGGCTTCG AGAAGATCGA GAGCCCCGTC TAGAGCAGCT ATTTCCTGAT ACCAGCACCC CTCGACCATT CCGTTTCGCA GGCAAGAGGA TATTCTTCTT AAGCAGTAGA GTACACCCAG GGGAGACTCC ATCTAGCTTT GTCTTCAATG GCTTTCTGGA CTTCATCCTC CGACCTGATG ATCCCCGGGC CCAAACCCTC CGTCGCCTCT TCGTCTTTAA GCTGATTCCC ATGTTGAACC CCGATGGTGT GGTCCGGGGA CACTACCGCA CAGACTCACG TGGAGTGAAT CTGAACCGTC AGTACCTGAA GCCTGATGCC GTCCTGCACC CGGCCATCTA TGGGGCCAAA GCTGTGCTTC TCTACCACCA TGTGCACTCT CGTCTGAACT CCCAGAGTTC CTCTGAGCAC CAGCCCAGTT CCTGTCTCCC TCCTGATGCT CCTGTTTCTG ACCTGGAGAA AGCCAACAAT CTCCAAAATG AAGCTCAGTG TGGGCACTCA GCTGACAGGC ATAACGCTGA AGCCTGGAAA CAAACAGAGC CAGCAGAACA GAAGCTCAAC AGTGTGTGGA TTATGCCACA ACAGTCTGCG GGGCTTGAAG AGTCAGCCCC TGATACCATC CCCCCCAAAG AGAGTGGCGT TGCTTACTAT GTGGACCTGC ATGGACATGC TTCCAAAAGG GGCTGCTTCA TGTACGGAAA CAGCTTTAGT GATGAGAGCA CCCAGGTGGA AAACATGCTA TATCCAAAGC TCATCTCCTT GAATTCAGCC CACTTCGACT TCCAGGGCTG CAATTTCTCA GAGAAGAATA TGTATGCCCG AGACCGTAGA GATGGCCAGT CTAAAGAGGG AAGCGGCCGT GTTGCAATCT ACAAAGCCTC AGGGATAATC CACAGCTACA CACTTGAATG CAACTACAAC ACTGGACGCT CAGTAAACAG CATCCCTGCT GCCTGCCATG ACAATGGGCG TGCCAGCCCC CCTCCCCCGC CGGCTTTCCC CTCCAGATAC ACTGTGGAAC TATTTGAGCA GGTGGGACGA GCTATGGCCA TTGCAGCCCT GGACATGGCG GAATGTAATC CGTGGCCCCG AATTGTACTG TCAGAGCACA GCAGCCTTAC TAATCTACGG GCCTGGATGC TGAAACATGT ACGCAACAGC CGAGGCCTAA GCAGCACTCT GAATGTGGGT GTCAACAAGA AGAGGGGCCT TCGAACTCCA CCCAAAAGTC ACAATGGGTT GCCTGTCTCC TGCTCCGAAA ACACCTTGAG TCGGGCACGA AGTTTTAGCA CCGGCACAAG TGCCGGTGGT AGCAGCAGCA GCCAACAAAA TTCTCCACAG ATGAAGAATT CCCCCAGCTT TCCTTTTCAT GGCAGTCGGC CTGCAGGGCT GCCAGGCCTG GGCTCTAGTA CCCAAAAGGT CACCCACCGG GTGCTGGGCC CCGTCAGAGA GCCCCGAAGC CAGGACAGGA GACGGCAGCA GCAGCCCCTG AACCATCGTC CTGCAGGCAG CCTCGCTCCA TCCCCAGCTC CTACTAGTTC TGGCCCAGCC TCCTCACACA AGCTGGGCTC CTGTCTACTG CCTGATTCAT TCAACATACC AGGGAGCAGT TGCTCACTCT TGTCCTCTGG AGACAAACCA GAGGCTGTCA TGGTAATCGG GAAAGGTCTG CTAGGGACTG GAGCTCGGAT GCCCTGCATC AAGACTCGAT TGCAGACCTG TCCGAGGAGA GTTTCCGCCA GGAGGGGTCC CGGATTCCCC AGGCTAGGCC CAGGTTGGGC CGGGGCTCAC CGCCGACTCG CAGAGGGATG A . It is sometimes possible for the material contained within the vial of "AGBL5, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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