CDKN2C recombinant protein

CDKN2C, 1-168aa, Human, His tag, E Coli

Cat. Num. AAA204203

• Gene Names: CDKN2C; p18; INK4C; p18-INK4C
• Applications: SDS-Page
• Purity: > 95% by SDS-PAGE
• Synonyms: CDKN2C; 1-168aa; Human; His tag; E Coli; Cyclin-dependent kinase 4 inhibitor C; INK4C; p18; p18-INK4C; CDKN2C recombinant protein

• Host: E Coli
• Purity/Purification: > 95% by SDS-PAGE
• Form/Format: Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 2mM DTT, 10% glycerol, 200mM NaCl
• Concentration: 0.5 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMAEPWG NELASAAARG DLEQLTSLLQ NNVNVNAQNG FGRTALQVMK LGNPEIARRL LLRGANPDLK DRTGFAVIHD AARAGFLDTL QTLLEFQADV NIEDNEGNLP LHLAAKEGHL RVVEFLVKHT ASNVGHRNHK GDTACDLARL YGRNEVVSLM QANGAGGATN LQ
• Sequence Length: 168

• Applicable Applications for CDKN2C recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for CDKN2C recombinant protein

CDKN2C (Cyclin-dependent kinase 4 inhibitor C) belongs to the CDKN2 cyclin-dependent kinase inhibitor family. It has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. And this protein suppresses the cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Recombinant human CDKN2C protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for CDKN2C recombinant protein

Cancer

References

Blais A, et al. (1998).) Biochem Biophys Res Commun 247 (1): 146-53.; Serrano M, et al. (1994). Nature 366 (6456): 704-7.

NCBI and Uniprot Product Information

• NCBI GI #: 4502751
• NCBI GeneID: 1031
• NCBI Accession #: NP_001253
• NCBI GenBank Nucleotide #: NM_001262.2
• UniProt Accession #: P42773; Q8TB83
• Molecular Weight: 20.7kDa (192aa), confirmed by MALDI-TOF
• NCBI Official Full Name: cyclin-dependent kinase 4 inhibitor C
• NCBI Official Synonym Full Names: cyclin dependent kinase inhibitor 2C
• NCBI Official Symbol: CDKN2C
• NCBI Official Synonym Symbols: p18; INK4C; p18-INK4C
• NCBI Protein Information: cyclin-dependent kinase 4 inhibitor C
• UniProt Protein Name: Cyclin-dependent kinase 4 inhibitor C
• Protein Family: Cyclin-dependent kinase 4 inhibitor
• UniProt Gene Name: CDKN2C
• UniProt Synonym Gene Names: CDKN6

NCBI Description

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.