p18 INK Blocking Peptide | CDKN2C blocking peptide

p18 INK4c Blocking Peptide

Cat. Num. AAA9617060

• Gene Names: CDKN2C; p18; INK4C; p18-INK4C
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: p18 INK; p18 INK4c Blocking Peptide; CDK6 inhibitor p18; CDKN 2C; CDKN 6; Cdkn2c; CDKN6; CDN2C_HUMAN; Cyclin dependent inhibitor; Cyclin dependent kinase 4 inhibitor C; Cyclin dependent kinase 6 inhibitor; Cyclin dependent kinase 6 inhibitor p18; Cyclin dependent kinase inhibitor 2C (p18 inhibits CDK4); Cyclin dependent kinase inhibitor 2C; Cyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; INK4C; OTTHUMP00000046546; p18; p18 inhibits CDK4; p18 INK4c; p18 INK6; p18-INK4c; p18-INK6; CDKN2C blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for CDKN2C blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CDKN2C blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 4502751
• NCBI GeneID: 1031
• NCBI Accession #: NP_001253.1
• NCBI GenBank Nucleotide #: NM_001262.2
• UniProt Accession #: P42773; Q8TB83
• Molecular Weight: 18,127 Da
• NCBI Official Full Name: cyclin-dependent kinase 4 inhibitor C
• NCBI Official Synonym Full Names: cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
• NCBI Official Symbol: CDKN2C
• NCBI Official Synonym Symbols: p18; INK4C; p18-INK4C
• NCBI Protein Information: cyclin-dependent kinase 4 inhibitor C; p18-INK6; CDK6 inhibitor p18; cyclin-dependent inhibitor; cyclin-dependent kinase 6 inhibitor p18
• UniProt Protein Name: Cyclin-dependent kinase 4 inhibitor C
• Protein Family: Cyclin-dependent kinase 4 inhibitor
• UniProt Gene Name: CDKN2C
• UniProt Synonym Gene Names: CDKN6
• UniProt Entry Name: CDN2C_HUMAN

NCBI Description

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

CDKN2C: Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. Heterodimer of p18 with CDK6. Highest levels found in skeletal muscle. Also found in pancreas and heart. Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.

Protein type: Cell cycle regulation; Protein kinase, regulatory subunit; Inhibitor

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: cytoplasm; nucleus; cytosol

Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding; protein kinase binding

Biological Process: negative regulation of cell proliferation; oligodendrocyte differentiation; negative regulation of phosphorylation; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; negative regulation of cell growth; cell cycle arrest; G1/S transition of mitotic cell cycle