Cyclin Dependent Kinase Inhibitor 2B Recombinant Protein | CDKN2B recombinant protein

Recombinant Cyclin Dependent Kinase Inhibitor 2B (CDKN2B)

Cat. Num. AAA2034374

• Gene Names: CDKN2B; P15; MTS2; TP15; CDK4I; INK4B; p15INK4b
• Reactivity: Mouse
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: >95%
• Synonyms: Cyclin Dependent Kinase Inhibitor 2B; Recombinant Cyclin Dependent Kinase Inhibitor 2B (CDKN2B); p15; INK4B; MTS2; TP15; Cyclin-dependent kinase 4 inhibitor B; Multiple tumor suppressor 2; CDKN2B recombinant protein

• Host: E Coli
• Reactivity: Mouse
• Purity/Purification: >95%
• Sequence Length: 138

• Applicable Applications for CDKN2B recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Fragment: Met1~Asp130
• Tag: Prokaryotic expression
• Preparation and Storage: Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 395440625
• NCBI GeneID: 1030
• Molecular Weight: 17.5kDa
• NCBI Official Full Name: cyclin-dependent kinase inhibitor 2B
• NCBI Official Synonym Full Names: cyclin-dependent kinase inhibitor 2B
• NCBI Official Symbol: CDKN2B
• NCBI Official Synonym Symbols: P15; MTS2; TP15; CDK4I; INK4B; p15INK4b
• NCBI Protein Information: cyclin-dependent kinase 4 inhibitor B
• UniProt Protein Name: Cyclin-dependent kinase 4 inhibitor B
• Protein Family: Cyclin-dependent kinase 4 inhibitor
• UniProt Gene Name: CDKN2B
• UniProt Synonym Gene Names: MTS2; MTS-2; p15INK4B
• UniProt Entry Name: CDN2B_HUMAN

NCBI Description

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

p15-INK4B: a potent inhibitor that nteracts strongly with CDK4 and CDK6. Potential effector of TGF-beta induced cell cycle arrest.

Protein type: Tumor suppressor; Protein kinase, regulatory subunit; Cell cycle regulation; Inhibitor

Chromosomal Location of Human Ortholog: 9p21

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding; protein kinase binding

Biological Process: cell cycle arrest; cellular response to extracellular stimulus; cellular response to nutrient; G2/M transition of mitotic cell cycle; gene expression; megakaryocyte differentiation; mitotic cell cycle; mitotic cell cycle checkpoint; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of cyclin-dependent protein kinase activity; spleen development; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway