Bovine cyclin-dependent kinase 5 ELISA Kit | CDK5 elisa kit
Bovine Cyclin-dependent kinase 5, CDK5 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
CDK5: a protein kinase of the CDK family. Unlike other members of this family, it is not activated by cyclins but by p35 (CDK5R1) and p39. An important regulator of neuronal positioning during brain development. May also play a role in synaptogenesis and neurotransmission. Substrates include TAU, MAP2, NF-H and -M, Nudel, PDE6, beta-catenin, amphyphysin, dynamin I, synapsin 1, Munc-18, and NMDA receptor 2A. Plays a role in myogenesis, haematopoietic cell differentiation, spermatogenesis, insulin secretion, and lens differentiation. Implicated in the pathology of neurofibrillary tangles and formation of senile plaques, hallmarks of Alzheimer?s disease. Induces tau phosphorylation and aggregation and neurofibrillary tangle deposition and neurodegeneration in in vitro and in vivo animal models. Brain samples from Alzeimer?s pateints show elevated CDK5 activity.
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Cell cycle regulation; Protein kinase, CMGC; Kinase, protein; CMGC group; CDK family; CDK/CDK5 subfamily; CDK5 subfamily
Cellular Component: postsynaptic density; dendrite; perikaryon; cytosol; postsynaptic membrane; growth cone; cell soma; membrane; lamellipodium; axon; cytoplasm; nucleus; cell junction; neuromuscular junction; filopodium
Molecular Function: acetylcholine receptor activator activity; protein serine/threonine kinase activity; ErbB-2 class receptor binding; ErbB-3 class receptor binding; p53 binding; cyclin-dependent protein kinase activity; tau-protein kinase activity; histone kinase activity; kinase activity; ATP binding
Biological Process: synaptic transmission, dopaminergic; Schwann cell development; negative regulation of synaptic plasticity; negative regulation of protein export from nucleus; positive regulation of protein binding; histone phosphorylation; cell-matrix adhesion; cerebellar cortex formation; neuron migration; rhythmic process; regulation of synaptic plasticity; motor axon guidance; negative regulation of axon extension; sensory perception of pain; regulation of cell migration; receptor clustering; negative regulation of cell cycle; neuron differentiation; corpus callosum development; intracellular protein transport; synaptogenesis; behavioral response to cocaine; receptor catabolic process; positive regulation of neuron apoptosis; oligodendrocyte differentiation; visual learning; layer formation in the cerebral cortex; neurite development; serine phosphorylation of STAT3 protein; central nervous system neuron development; negative regulation of proteolysis; synaptic transmission, glutamatergic; skeletal muscle development; cell migration; dendrite morphogenesis; hippocampus development; peptidyl-threonine phosphorylation; cell cycle; positive regulation of calcium ion-dependent exocytosis; neuron apoptosis; axonogenesis; cell division; positive regulation of protein kinase activity; negative regulation of protein ubiquitination; regulation of excitatory postsynaptic membrane potential; negative regulation of transcription, DNA-dependent
Research Articles on CDK5
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Product Notes
The Bovine CDK5 cdk5 (Catalog #AAA9319558) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9319558 ELISA Kit recognizes Bovine CDK5. It is sometimes possible for the material contained within the vial of "cyclin-dependent kinase 5, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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