Cell division control protein 48 (CDC48) Recombinant Protein | CDC48 recombinant protein

Recombinant Saccharomyces cerevisiae Cell division control protein 48 (CDC48) , partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Cell division control protein 48 (CDC48); Recombinant Saccharomyces cerevisiae Cell division control protein 48 (CDC48); partial; CDC48 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 835

• Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 6320077
• NCBI GeneID: 851431
• NCBI Accession #: NP_010157.1
• NCBI GenBank Nucleotide #: NM_001180185.1
• UniProt Accession #: P25694; D6VRM4
• Molecular Weight: 91,996 Da
• NCBI Official Full Name: AAA family ATPase CDC48
• NCBI Official Symbol: CDC48
• NCBI Protein Information: AAA family ATPase CDC48
• UniProt Protein Name: Cell division control protein 48
• Protein Family: Cell division cycle protein
• UniProt Gene Name: CDC48

Uniprot Description

Involved in spindle disassembly, degradation of ubiquitinated proteins and protein export from the endoplasmic reticulum to the cytoplasm. Acts as a chaperone that collects ubiquitinated substrates. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway. Required for the proteasome-dependent processing/activation of MGA2 and SPT23 transcription factors leading to the subsequent expression of OLE1. Has an additional role in the turnover of OLE1 where it targets ubiquitinated OLE1 and other proteins to the ERAD (PubMed:11733065, PubMed:11740563, PubMed:11813000, PubMed:11847109, PubMed:21070972, PubMed:21148305). Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. CDC48 may provide the mechanical force that dislodges the polyubiquitinated nascent peptides from the exit channel (PubMed:23178123, PubMed:24261871).