Dual specificity protein phosphatase CDC14A (CDC14A) Recombinant Protein | CDC14A recombinant protein

Recombinant Human Dual specificity protein phosphatase CDC14A (CDC14A)

Cat. Num. AAA1414368

• Gene Names: CDC14A; cdc14; hCDC14; DFNB105
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Dual specificity protein phosphatase CDC14A (CDC14A); Recombinant Human Dual specificity protein phosphatase CDC14A (CDC14A); CDC14A recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-594, Full length protein
• Sequence: MAAESGELIGACEFMKDRLYFATLRNRPKSTVNTHYFSIDEELVYENFYADFGPLNLAMVYRYCCKLNKKLKSYSLSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFDVDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNRPSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLSSSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTTRNYPELNNNQYNRSSNSNGGNLNSPPGPHSAKTEEHTTILRPSYTGLSSSSARFLSRSIPSLQSEYVHY
• Sequence Length: 594

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for CDC14A recombinant protein

This protein is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms.

NCBI and Uniprot Product Information

• NCBI GI #: 984655777
• NCBI GeneID: 8556
• NCBI Accession #: NP_001306139.1
• NCBI GenBank Nucleotide #: NM_001319210.1
• UniProt Accession #: Q9UNH5; O43171; O60727; O60728; Q52LH9; Q8IXX0; A6MA65; B1AQ14; B1AQ15
• Molecular Weight: 68,203 Da
• NCBI Official Full Name: dual specificity protein phosphatase CDC14A isoform 4
• NCBI Official Synonym Full Names: cell division cycle 14A
• NCBI Official Symbol: CDC14A
• NCBI Official Synonym Symbols: cdc14; hCDC14; DFNB105
• NCBI Protein Information: dual specificity protein phosphatase CDC14A
• UniProt Protein Name: Dual specificity protein phosphatase CDC14A
• Protein Family: Dual specificity protein phosphatase
• UniProt Gene Name: CDC14A

NCBI Description

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis.