Human CDC14 cell division cycle 14 homolog A (S. cerevisiae) ELISA Kit | CDC14A elisa kit
Human Dual specificity protein phosphatase CDC14A, CDC14A ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
CDC14A: Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC- FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Protein phosphatase, dual-specificity; Motility/polarity/chemotaxis; EC 3.1.3.48; EC 3.1.3.16
Chromosomal Location of Human Ortholog: 1p21
Cellular Component: nucleoplasm; centrosome; cytoplasm; spindle; nucleus
Molecular Function: protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; phosphoprotein phosphatase activity
Biological Process: cell proliferation; cell division; cell cycle
Research Articles on CDC14A
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Product Notes
The Human CDC14A cdc14a (Catalog #AAA9323120) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9323120 ELISA Kit recognizes Human CDC14A. It is sometimes possible for the material contained within the vial of "CDC14 cell division cycle 14 homolog A (S. cerevisiae), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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