CDA recombinant protein

Recombinant Human CDA protein

Cat. Num. AAA1561777

• Gene Names: CDA; CDD
• Purity: >90% as determined by SDS-PAGE
• Synonyms: CDA; Recombinant Human CDA protein; Cytidine deaminase; Cytidine aminohydrolase; CDA recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human CDA (Ala2-Gln146) was fused with His tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for CDA recombinant protein

Sclerostin, the protein product of the SOST gene, is a potent inhibitor of bone formation. Sclerostin protein is widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteeoblasts differentiated for 21 days, and was originally identified as an important regulator of bone remodeling, homeostasis, and links bone resorption and bone apposition. Recent studies have revealed that Sclerostin protein inhibits the bone growth probably by binding to the extracellular domain of the Wnt coreceptors LRP5 and LRP6 and disrupting Wnt-induced Frizzled-LRP complex formation.

Product Categories/Family for CDA recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 1705718
• NCBI GeneID: 978
• UniProt Accession #: P32320
• Molecular Weight: 146
• NCBI Official Full Name: Cytidine deaminase
• NCBI Official Synonym Full Names: cytidine deaminase
• NCBI Official Symbol: CDA
• NCBI Official Synonym Symbols: CDD
• NCBI Protein Information: cytidine deaminase; cytidine aminohydrolase; small cytidine deaminase; cytosine nucleoside deaminase
• UniProt Protein Name: Cytidine deaminase
• Protein Family: Colicin
• UniProt Gene Name: CDA
• UniProt Synonym Gene Names: CDD
• UniProt Entry Name: CDD_HUMAN

NCBI Description

This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]

Uniprot Description

CDA: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. Belongs to the cytidine and deoxycytidylate deaminase family.

Protein type: Nucleotide Metabolism - pyrimidine; Hydrolase; Xenobiotic Metabolism - drug metabolism - other enzymes; EC 3.5.4.5

Chromosomal Location of Human Ortholog: 1p36.2-p35

Cellular Component: extracellular region; cytosol

Molecular Function: protein homodimerization activity; zinc ion binding; nucleoside binding; cytidine deaminase activity

Biological Process: cell surface receptor linked signal transduction; pyrimidine base metabolic process; cytosine metabolic process; nucleobase, nucleoside and nucleotide metabolic process; pyrimidine nucleoside salvage; cytidine deamination; negative regulation of cell growth; pyrimidine salvage; negative regulation of nucleotide metabolic process; protein homotetramerization