Signaling Lymphocytic Activation Molecule Family, Member 5 (SLAMF5) Recombinant Protein | SLAMF5 recombinant protein

Recombinant Signaling Lymphocytic Activation Molecule Family, Member 5 (SLAMF5)

Cat. Num. AAA2018681

• Gene Names: CD84; LY9B; hCD84; mCD84; SLAMF5
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: > 95%
• Synonyms: Signaling Lymphocytic Activation Molecule Family; Member 5 (SLAMF5); Recombinant Signaling Lymphocytic Activation Molecule Family; SLAMF5 recombinant protein

• Host: E Coli
• Purity/Purification: > 95%
• Form/Format: Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Sequence: The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.; MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- IQEPRQVK IIAWTSKTSV AYVTPGDSET APVVTVTHRN YYERIHALGP NYNLVISDLR MEDAGDYKAD INTQADPYTT TKRYNLQIYR RLGKPKITQS LMASVNSTCN VTLTCSVEKE EKNVTYNWSP LGEEGNVLQI FQTPEDQELT YTCTAQNPVS NNSDSISARQ LCADIAMGFR THHTGLLSVL AMFFLLVLILSSVFLFRL
• Sequence Length: 345

• Applicable Applications for SLAMF5 recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Organism: Homo sapiens (Human)
• Expression System: Prokaryotic expression
• Residues: Ile43~Leu248 (Accession # Q9UIB8) with two N-terminal Tags, His-tag and T7-tag
• Subcellular Location: Cell membrane; Single-pass type I membrane protein
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Predicted Isoelectric Point: 6.8
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 296434285
• NCBI GeneID: 8832
• NCBI Accession #: NP_001171808.1
• NCBI GenBank Nucleotide #: NM_001184879.1
• UniProt Accession #: Q9UIB8; O15430; O95266; O95660; Q5H9R1; Q6FHA8; Q8WLP1; Q8WWI8; Q9UF04; Q9UIB6; B2R8T1; B7Z3R8
• Molecular Weight: 27.0kDa
• NCBI Official Full Name: SLAM family member 5 isoform 1
• NCBI Official Synonym Full Names: CD84 molecule
• NCBI Official Symbol: CD84
• NCBI Official Synonym Symbols: LY9B; hCD84; mCD84; SLAMF5
• NCBI Protein Information: SLAM family member 5; hly9-beta; leukocyte antigen CD84; cell surface antigen MAX.3; CD84 antigen (leukocyte antigen); leucocyte differentiation antigen CD84; leukocyte differentiation antigen CD84; signaling lymphocytic activation molecule 5
• UniProt Protein Name: SLAM family member 5
• UniProt Gene Name: CD84
• UniProt Synonym Gene Names: SLAMF5
• UniProt Entry Name: SLAF5_HUMAN

NCBI Description

This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

Uniprot Description

CD84: Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain- containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell surface; Motility/polarity/chemotaxis; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 1q24

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; receptor activity

Biological Process: defense response; blood coagulation; homophilic cell adhesion; leukocyte migration