SDS-Page
(Figure 1. Human CD5L Protein, His Tag on SDS-PAGE under reducing condition.)
CD5L Recombinant Protein | CD5 recombinant protein
Human CD5L Protein, His Tag
Gene Names
CD5L; AIM; API6; CT-2; hAIM; PRO229; Spalpha; SP-ALPHA
Purity
>95%; affinity purification
Synonyms
CD5L; Human CD5L Protein; His Tag; AIM; API6; CT-2; hAIM; PRO229; SP-ALPHA; Spalpha; CD5 recombinant protein
Host
HEK293 cells
Purity/Purification
>95%; affinity purification
Form/Format
Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose is added as protectants before lyophilization.
Sequence
CD5L (Ser20-Gly347)+6×His tag
Species
Human
Tag
C-6×His tag
Reconstitution
Reconstitute with deionized water
Preparation and Storage
Store at -80 degree C for 12 months (Avoid repeated freezing and thawing)
SDS-Page
(Figure 1. Human CD5L Protein, His Tag on SDS-PAGE under reducing condition.)
SDS-Page
(Figure 1. Human CD5L Protein, His Tag on SDS-PAGE under reducing condition.)
Related Product Information for CD5 recombinant protein
Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). Acts as a key regulator of metabolic switch in T-helper Th17 cells. Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation. CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes. Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (By similarity). Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:24295828). Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (PubMed:16030018, PubMed:24223991, PubMed:24583716, PubMed:25713983).[UniProtKB/Swiss-Prot Function]
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
38,088 Da
NCBI Official Full Name
CD5 antigen-like
NCBI Official Synonym Full Names
CD5 molecule like
NCBI Official Symbol
CD5L
NCBI Official Synonym Symbols
AIM; API6; CT-2; hAIM; PRO229; Spalpha; SP-ALPHA
NCBI Protein Information
CD5 antigen-like
UniProt Protein Name
CD5 antigen-like
Protein Family
UniProt Gene Name
CD5L
UniProt Synonym Gene Names
API6; hAIM
UniProt Entry Name
CD5L_HUMAN
Uniprot Description
CD5L: May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis.
Protein type: Receptor, misc.; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q23.1
Cellular Component: extracellular space
Biological Process: cellular defense response
Similar Products
Product Notes
The CD5 cd5l (Catalog #AAA188793) is a Recombinant Protein produced from HEK293 cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: CD5L (Ser20-Gly 347)+6×Hi s tag. It is sometimes possible for the material contained within the vial of "CD5L, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
