CD5 recombinant protein

CD5, 25-372aa, Human, His-tag, Baculovirus

Cat. Num. AAA206540

• Gene Names: CD5; T1; LEU1
• Applications: SDS-Page
• Purity: > 95% by SDS-PAGE
• Synonyms: CD5; 25-372aa; Human; His-tag; Baculovirus; T-cell surface glycoprotein CD5; LEU1; T1; CD5 recombinant protein

• Host: Baculovirus
• Purity/Purification: > 95% by SDS-PAGE
• Form/Format: Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.
• Concentration: 0.5 mg/ml (determined by Absorbance at 280nm) (varies by lot)
• Sequence: ADPEFRLSWY DPDFQARLTR SNSKCQGQLE VYLKDGWHMV CSQSWGRSSK QWEDPSQASK VCQRLNCGVP LSLGPFLVTY TPQSSIICYG QLGSFSNCSH SRNDMCHSLG LTCLEPQKTT PPTTRPPPTT TPEPTAPPRL QLVAQSGGQH CAGVVEFYSG SLGGTISYEA QDKTQDLENF LCNNLQCGSF LKHLPETEAG RAQDPGEPRE HQPLPIQWKI QNSSCTSLEH CFRKIKPQKS GRVLALLCSG FQPKVQSRLV GGSSICEGTV EVRQGAQWAA LCDSSSARSS LRWEEVCREQ QCGSVNSYRV LDAGDPTSRG LFCPHQKLSQ CHELWERNSY CKKVFVTCQD PNPHHHHHH
• Sequence Length: 495

• Applicable Applications for CD5 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Endotoxin Level: < 1.0 EU per 1 microgram of protein (determined by LAL method)
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for CD5 recombinant protein

CD5, as known as T-cell surface glycoprotein CD5, is a transmembrane glycoprotein in the scavenger receptor superfamily. This protein was found expressed in small lymphocytic lymphoma, hairy cell leukemia and mantle cell lymphoma cells. CD5 expression on developing thymocytes is positively regulated by signaling through the T cell antigen receptor and is up-regulated peripheral CD4+ cell. Also, its Signaling inhibits the generation of regulatory T cells but promotes the development of Th17 cells. Recombinant human CD5, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Categories/Family for CD5 recombinant protein

Immunology

References

Cenit MC., et al, (2014) PLoS ONE 9:E113090.; Alinari L., et al, (2016) Am. J. Hematol. 91:395-399.

NCBI and Uniprot Product Information

• NCBI GI #: 166197668
• NCBI GeneID: 921
• NCBI Accession #: NP_055022
• NCBI GenBank Nucleotide #: NM_014207.3
• UniProt Accession #: P06127; A0N0P4; A8K9I3
• Molecular Weight: 40.0kDa (359aa) 40-57kDa (SDS-PAGE under reducing conditions.)
• NCBI Official Full Name: T-cell surface glycoprotein CD5 isoform 1
• NCBI Official Synonym Full Names: CD5 molecule
• NCBI Official Symbol: CD5
• NCBI Official Synonym Symbols: T1; LEU1
• NCBI Protein Information: T-cell surface glycoprotein CD5
• UniProt Protein Name: T-cell surface glycoprotein CD5
• Protein Family: CD5 antigen
• UniProt Gene Name: CD5
• UniProt Synonym Gene Names: LEU1

NCBI Description

This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes, T lymphocytes and a subset of B lymphocytes. The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]

Uniprot Description

May act as a receptor in regulating T-cell proliferation.