CD44 antigen Recombinant Protein | Cd44 recombinant protein

CD44 antigen

Cat. Num. AAA7042461

• Gene Names: Cd44; CD44A; METAA; RHAMM
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: CD44 antigen; Cd44 recombinant protein

• Host: Cell Free Expression
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Liquid containing glycerol
• Sequence Positions: 22-503aa; full length protein
• Sequence: QQQIDLNITCRYAGVFHVEKNGRYSISRTEAADLCEAFNTTLPTMAQMELALRKGFETCRYGFIEGHVVIPRIHPNAICAANNTGVYILLASNTSHYDTYCFNASAPLEEDCTSVTDLPNSFDGPVTITIVNRDGTRYSKKGEYRTHQEDIDASNIIDEDVSSGSTIEKSTPEGYILHTDLPTSQPTGDRDDAFFIGSTLATIATTPWVSAHTKQNQERTQWNPIHSNPEVLLQTTTRMTDIDRNSTSAHGENWTQEPQPPFNNHEYQDEEETPHATSTTWADPNSTTEEAATQKEKWFENEWQGKNPPTPSEDSHVTEGTTASAHNNHPSQRMTTQSQEDVSWTDFFDPISHPMGQGHQTESKGHSSGNQDSGVTTTSGPARRPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGTVEDRKPSELNGEASKSQEMVHLVNKEPTETPDQFMTADETRNLQSVDMKIGV
• Sequence Length: 503

• Species: Rattus norvegicus (Rat)
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.; Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for Cd44 recombinant protein

This is a recombinant transmembrane protein expressed in a cell-free expression system.

Product Categories/Family for Cd44 recombinant protein

Transmembrane Protein

NCBI and Uniprot Product Information

• NCBI GI #: 564342041
• NCBI GeneID: 25406
• NCBI Accession #: XP_006234693.1
• NCBI GenBank Nucleotide #: XM_006234631.3
• UniProt Accession #: P26051; Q99021
• Molecular Weight: 39,794 Da
• NCBI Official Full Name: CD44 antigen isoform X8
• NCBI Official Synonym Full Names: CD44 molecule (Indian blood group)
• NCBI Official Symbol: Cd44
• NCBI Official Synonym Symbols: CD44A; METAA; RHAMM
• NCBI Protein Information: CD44 antigen
• UniProt Protein Name: CD44 antigen
• Protein Family: CD44 antigen
• UniProt Gene Name: Cd44
• UniProt Synonym Gene Names: ECMR-III; PGP-1; PGP-I
• UniProt Entry Name: CD44_RAT

NCBI Description

adhesion molecule involved in migration, cell fusion and resportion in osteoclasts that also plays a role in cellular metastasis [RGD, Feb 2006]

Uniprot Description

CD44: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis

Cellular Component: apical plasma membrane; basolateral plasma membrane; cell surface; cytoplasm; external side of plasma membrane; focal adhesion; Golgi apparatus; nucleus; plasma membrane; protein complex

Molecular Function: cytokine binding; epidermal growth factor receptor binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; hyaluronic acid binding; hyalurononglucosaminidase activity; phosphoprotein binding; protein binding; protein kinase binding; punt binding

Biological Process: blood vessel maturation; cartilage development; cell adhesion; cell migration; healing during inflammatory response; hyaluronan catabolic process; inflammatory response; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of inflammatory response; negative regulation of mature B cell apoptosis; negative regulation of regulatory T cell differentiation; neurite development; positive regulation of heterotypic cell-cell adhesion; positive regulation of kinase activity; positive regulation of neutrophil apoptosis; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; regulation of cell growth; response to organic cyclic substance; response to vitamin A; ureteric bud branching; Wnt receptor signaling pathway