CD44 antigen Recombinant Protein | Cd44 recombinant protein
CD44 antigen
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
adhesion molecule involved in migration, cell fusion and resportion in osteoclasts that also plays a role in cellular metastasis [RGD, Feb 2006]
Uniprot Description
CD44: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, misc.; Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis
Cellular Component: apical plasma membrane; basolateral plasma membrane; cell surface; cytoplasm; external side of plasma membrane; focal adhesion; Golgi apparatus; nucleus; plasma membrane; protein complex
Molecular Function: cytokine binding; epidermal growth factor receptor binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; hyaluronic acid binding; hyalurononglucosaminidase activity; phosphoprotein binding; protein binding; protein kinase binding; punt binding
Biological Process: blood vessel maturation; cartilage development; cell adhesion; cell migration; healing during inflammatory response; hyaluronan catabolic process; inflammatory response; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of inflammatory response; negative regulation of mature B cell apoptosis; negative regulation of regulatory T cell differentiation; neurite development; positive regulation of heterotypic cell-cell adhesion; positive regulation of kinase activity; positive regulation of neutrophil apoptosis; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; regulation of cell growth; response to organic cyclic substance; response to vitamin A; ureteric bud branching; Wnt receptor signaling pathway