CD40L recombinant protein

Recombinant Human CD40L protein, C-His Tag

Cat. Num. AAA157434

• Gene Names: CD40LG; CD40L
• Purity: >90% as determined by SDS-PAGE
• Synonyms: CD40L; Recombinant Human CD40L protein; C-His Tag; TNFSF5; CD40L recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from 50 mM Tris-HCl pH 7.4, 150 mM NaCl, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Human
• Reconstitution: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details
• Construction: A DNA sequence encoding the human CD40LG (Glu108~Leu261) was fused with the C-terminal His Tag
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; Shipping: In general, proteins are provided as lyophilized powder/frozen liquid.

SDS-Page

Product Categories/Family for CD40L recombinant protein

Other proteins

NCBI and Uniprot Product Information

• NCBI GI #: 74136239
• NCBI GeneID: 574160
• NCBI Accession #: NP_001028011.1
• NCBI GenBank Nucleotide #: NM_001032839.1
• UniProt Accession #: P63304; Q9BDC7
• Molecular Weight: 29,366 Da
• NCBI Official Full Name: CD40 ligand
• NCBI Official Symbol: CD40LG
• NCBI Official Synonym Symbols: CD40L
• NCBI Protein Information: CD40 ligand
• UniProt Protein Name: CD40 ligand
• UniProt Gene Name: CD40LG
• UniProt Synonym Gene Names: CD40L; TNFSF5; CD40-L

Uniprot Description

Cytokine that binds to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching.