T-cell surface glycoprotein CD3 delta chain (CD3D) Recombinant Protein | CD3D recombinant protein

Recombinant Macaca fascicularis T-cell surface glycoprotein CD3 delta chain (CD3D), partial

Cat. Num. AAA1336304

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: T-cell surface glycoprotein CD3 delta chain (CD3D); Recombinant Macaca fascicularis T-cell surface glycoprotein CD3 delta chain (CD3D); partial; CD3D recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 22-105
• Sequence: FKIPVEELE DRVFVKCNTS VTWVEGTVGT LLTNNTRLDL GKRILDPRGI YRCNGTDIYK DKESAVQVHY RMCQNCVELD PATLA
• Sequence Length: 84

• Species: Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 567315991
• NCBI GeneID: 102133701
• NCBI Accession #: NP_001274617.1
• NCBI GenBank Nucleotide #: NM_001287688.1
• UniProt Accession #: Q95LI8
• Molecular Weight: 18,960 Da
• NCBI Official Full Name: T-cell surface glycoprotein CD3 delta chain
• NCBI Official Symbol: CD3D
• NCBI Protein Information: T-cell surface glycoprotein CD3 delta chain
• UniProt Protein Name: T-cell surface glycoprotein CD3 delta chain
• Protein Family: T-cell surface glycoprotein
• UniProt Gene Name: CD3D

Uniprot Description

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells.