CD38 recombinant protein

Recombinant Mouse CD38 Protein (C-Fc)

Cat. Num. AAA2557529

• Gene Names: Cd38; I-19; ADPRC 1; Cd38-rs1
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: CD38; Recombinant Mouse CD38 Protein (C-Fc); cADPr hydrolase 1; CD38 antigen (p45); CD38 antigen; CD38 molecule; Cyclic ADP-ribose hydrolase 1; Cyclic ADP-ribose Hydrolase; EC 3.2.2.5; NAD(+) nucleosidase; T10; CD38 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, PH7.0.
• Sequence: Leu45-Thr304
• Sequence Length: 304

• Species: Mouse
• Endotoxin: < 1.0 EU per mug as determined by the LAL method.
• Fusion Tag: C-Fc
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for CD38 recombinant protein

Protein Construction: Recombinant Mouse CD38 is produced by our mammalian expression system and the target gene encoding Leu45-Thr304 is expressed with a Fc tag at the C-terminus.

Background: CD38, also called ADP-ribosyl cyclase, is a Type II integral membrane protein with 301 amino acids in length that belongs to the ADP-ribosyl cyclase family. It synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. And also moonlights as a receptor in cells of the immune system. CD38 is expressed in B and T lymphocytes, osteoclasts, and in cardiac, pancreatic, liver and kidney cells. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in many types of cells, including neutrophils and pancreatic beta cells.

NCBI and Uniprot Product Information

• NCBI GI #: 31542362
• NCBI GeneID: 12494
• NCBI Accession #: NP_031672.2
• NCBI GenBank Nucleotide #: NP_031672.2
• UniProt Accession #: P56528
• Molecular Weight: Molecular Mass: 56.9kDa; Actual Protein Molecular Mass: 70-90kDa
• NCBI Official Full Name: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
• NCBI Official Synonym Full Names: CD38 antigen
• NCBI Official Symbol: Cd38
• NCBI Official Synonym Symbols: I-19; ADPRC 1; Cd38-rs1
• NCBI Protein Information: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
• UniProt Protein Name: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
• Protein Family: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
• UniProt Gene Name: Cd38
• UniProt Synonym Gene Names: ADPRC 1; cADPr hydrolase 1
• UniProt Entry Name: CD38_MOUSE

NCBI Description

This gene encodes a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Knockout mice deficient for this gene display altered humoral immune responses. In addition, knockout mice exhibit higher locomotor activity and defects in nurturing and social behaviors. [provided by RefSeq, Sep 2015]

Uniprot Description

CD38: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lyase; Hydrolase; EC 3.2.2.6; EC 2.4.99.20; Cell surface; Cell cycle regulation; Apoptosis; Membrane protein, integral; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide

Cellular Component: cell surface; membrane; intracellular membrane-bound organelle; integral to membrane; plasma membrane; cytosol; nucleus

Molecular Function: transferase activity; phosphorus-oxygen lyase activity; hydrolase activity; hydrolase activity, acting on glycosyl bonds; NAD+ nucleosidase activity; NAD(P)+ nucleosidase activity

Biological Process: response to drug; metabolic process; positive regulation of transcription, DNA-dependent; response to hormone stimulus; positive regulation of insulin secretion; positive regulation of cell growth; B cell receptor signaling pathway; elevation of cytosolic calcium ion concentration; response to hydroperoxide; response to hypoxia; positive regulation of B cell proliferation; positive regulation of vasoconstriction; negative regulation of transcription, DNA-dependent; negative regulation of bone resorption; negative regulation of apoptosis