CD34 recombinant protein
Recombinant Human CD34 GST Tag
Sterile Filtered clear solution.
Introduction: CD34 is a single chain transmembrane glycoprotein which is selectively expressed on human lymphoid and myeloid hemapoietic progenitor cells.CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Uniprot Description
CD34: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. Belongs to the CD34 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q32
Cellular Component: intercellular bridge; perinuclear region of cytoplasm; lysosome; integral to plasma membrane; cytoplasm; apical plasma membrane; basal plasma membrane; plasma membrane; external side of plasma membrane
Molecular Function: sulfate binding; carbohydrate binding; transcription factor binding
Biological Process: positive regulation of odontogenesis; cell proliferation; positive regulation of angiogenesis; cell-cell adhesion; regulation of immune response; negative regulation of nitric oxide biosynthetic process; endothelial cell proliferation; regulation of blood pressure; glomerular filtration; cell motility involved in cell locomotion; tissue homeostasis; negative regulation of blood coagulation; hemopoiesis; negative regulation of tumor necrosis factor production; signal transduction; leukocyte migration; positive regulation of interleukin-10 production
Research Articles on CD34
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Product Notes
The CD34 cd34 (Catalog #AAA142848) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CD34, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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