CD300C recombinant protein

CD300C Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8120989

• Gene Names: CD300C; LIR; CLM-6; CMRF35; IGSF16; CMRF-35; CMRF35A; CMRF-35A; CMRF35A1; CMRF35-A1
• Purity: >95% as determined by SDS-PAGE
• Synonyms: CD300C; CD300C Protein; Human; Recombinant (His Tag); Human CD300C/CMRF-35/IGSF16 Protein (His Tag); CLM-6 Protein; CMRF-35 Protein; CMRF-35A Protein; CMRF35 Protein; CMRF35-A1 Protein; CMRF35A Protein; CMRF35A1 Protein; IGSF16 Protein; LIR Protein; CD300c molecule; CD300C recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Arg183

• Species: Human
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Met 29
• Tag: C-His
• Protein Construction: A DNA sequence encoding the human CD300C (NP_006669.1) extracellular domain (Met 1-Arg 183) was expressed, with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for CD300C recombinant protein

Background: The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD300 is a glycoprotein family of cell surface molecules that regulate a diverse array of cellular processes via their triggering and inhibitory receptor functions. The CD300 family of myeloid immunoglobulin receptors includes activating(CD300b, CD300e) and inhibitory members(CD300a, CD300f), as well as CD300c and CD300d, whose function is uncertain.

Product Categories/Family for CD300C recombinant protein

ITIM/ITAM Immunoreceptors and Related Molecules

References

Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.Lankry D, et al. (2010) Expression and function of CD300 in NK cells.185(5): 2877-86.Agueda MB, et al. (2010) CD300 heterocomplexes, a new and family-restricted mechanism for myeloid cell signaling regulation. Journal of biological chemistry. 285: 41781-94.Clark GJ, et al. (2009) The CD300 molecules regulate monocyte and dendritic cell functions. 214 (9-10): 730-6.

NCBI and Uniprot Product Information

• NCBI GI #: 5729776
• NCBI GeneID: 10871
• NCBI Accession #: NP_006669.1
• NCBI GenBank Nucleotide #: NM_006678.4
• UniProt Accession #: Q08708
• Molecular Weight: 24,830 Da
• NCBI Official Full Name: CMRF35-like molecule 6
• NCBI Official Synonym Full Names: CD300c molecule
• NCBI Official Symbol: CD300C
• NCBI Official Synonym Symbols: LIR; CLM-6; CMRF35; IGSF16; CMRF-35; CMRF35A; CMRF-35A; CMRF35A1; CMRF35-A1
• NCBI Protein Information: CMRF35-like molecule 6; CD300 antigen-like family member C; CD300c antigen; CMRF35 antigen; CMRF35 leukocyte immunoglobulin-like receptor; CMRF35A leukocyte immunoglobulin-like receptor; immunoglobulin superfamily member 16
• UniProt Protein Name: CMRF35-like molecule 6
• Protein Family: CMRF35-like molecule
• UniProt Gene Name: CD300C
• UniProt Synonym Gene Names: CMRF35; CMRF35A; CMRF35A1; IGSF16; CLM-6; CMRF-35; IgSF16
• UniProt Entry Name: CLM6_HUMAN

NCBI Description

The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992 [PubMed 1349532]).[supplied by OMIM, Mar 2008]

Uniprot Description

CD300C: Belongs to the CD300 family

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q25.1

Cellular Component: integral to plasma membrane

Molecular Function: transmembrane receptor activity

Biological Process: immune system process; cellular defense response; signal transduction