Chemokine C-C-Motif Receptor 10 (CCR10) Recombinant Protein | CCR10 recombinant protein

Recombinant Chemokine C-C-Motif Receptor 10 (CCR10)

Cat. Num. AAA2105324

• Gene Names: CCR10; GPR2
• Applications: SDS-Page, Western Blot
• Purity: > 90%
• Synonyms: Chemokine C-C-Motif Receptor 10 (CCR10); Recombinant Chemokine C-C-Motif Receptor 10 (CCR10); GPR2; G Protein-Coupled Receptor 2; CCR10 recombinant protein

• Host: Host: E Coli; Source: Prokaryotic Expression
• Purity/Purification: > 90%
• Form/Format: Freeze-Dried Powder; PBS, pH7.4, Containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Sequence Positions: Met1~Ser78
• Sequence Length: 362

• Applicable Applications for CCR10 recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Species: Human
• Tag: N-terminal His-Tag
• Isoelectric Point: 4.6
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Subcellular Location: Membrane
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
• Preparation and Storage: Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Avoid repeated freeze/thaw cycles.; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

Product Categories/Family for CCR10 recombinant protein

Signal transduction; CD & Adhesion molecule; Tumor immunity; Infection immunity; Dermatology

NCBI and Uniprot Product Information

• NCBI GI #: 156104886
• NCBI GeneID: 2826
• NCBI Accession #: NP_057686.2
• NCBI GenBank Nucleotide #: NM_016602.3
• UniProt Accession #: P46092
• Molecular Weight: Predicted MW: 11.9kDa; Accurate MW: 15kDa
• NCBI Official Full Name: C-C chemokine receptor type 10
• NCBI Official Synonym Full Names: C-C motif chemokine receptor 10
• NCBI Official Symbol: CCR10
• NCBI Official Synonym Symbols: GPR2
• NCBI Protein Information: C-C chemokine receptor type 10
• UniProt Protein Name: C-C chemokine receptor type 10
• Protein Family: C-C chemokine receptor
• UniProt Gene Name: CCR10
• UniProt Synonym Gene Names: GPR2; C-C CKR-10; CC-CKR-10; CCR-10
• UniProt Entry Name: CCR10_HUMAN

NCBI Description

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]

Uniprot Description

CCR10: Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 17q21.1-q21.3

Cellular Component: cell surface; integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; C-C chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; immune response; chemotaxis