Cyclin E1 ELISA Kit | CCNE1 elisa kit

Cyclin E1 Colorimetric Cell-Based ELISA Kit

Cat. Num. AAA9500164

• Gene Names: CCNE1; CCNE; pCCNE1
• Reactivity: Human, Mouse, Rat
• Synonyms: Cyclin E1; Cyclin E1 Colorimetric Cell-Based ELISA Kit; CCNE; CCNE1; G1/S-specific cyclin E1; CCNE1 elisa kit

• Reactivity: Human, Mouse, Rat
• Form/Format: One 96-Well Plate
• Sequence Length: 410

• Samples: Researchers plate their cell line of choice
• Assay Type: Non-Phospho Cell-Based ELISA
• Sensitivity: >=5000 cells/well
• Detection Method: Colorimetric 450 nm
• Preparation and Storage: Store at 4 degree C.

Product Categories/Family for CCNE1 elisa kit

Cell Based ELISA Kit

NCBI and Uniprot Product Information

• NCBI GI #: 17318559
• NCBI GeneID: 898
• NCBI Accession #: NP_001229.1
• NCBI GenBank Nucleotide #: NM_001238.3
• UniProt Accession #: P24864; Q14091; Q8NFG1; Q92501; Q9UD21; A8K684
• Molecular Weight: 47077
• NCBI Official Full Name: G1/S-specific cyclin-E1 isoform 1
• NCBI Official Synonym Full Names: cyclin E1
• NCBI Official Symbol: CCNE1
• NCBI Official Synonym Symbols: CCNE; pCCNE1
• NCBI Protein Information: G1/S-specific cyclin-E1
• UniProt Protein Name: G1/S-specific cyclin-E1
• UniProt Gene Name: CCNE1
• UniProt Synonym Gene Names: CCNE

NCBI Description

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]

Uniprot Description

CCNE1: a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Two alternatively spliced isoforms have been described.

Protein type: Activator; Cell cycle regulation; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 19q12

Cellular Component: cytosol; nucleoplasm; nucleus

Molecular Function: androgen receptor binding; cyclin-dependent protein kinase regulator activity; kinase activity; protein binding; protein kinase binding; transcription coactivator activity

Biological Process: androgen receptor signaling pathway; cell division; DNA replication initiation; G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; protein amino acid phosphorylation; regulation of cell cycle; regulation of protein kinase activity; synapsis; telomere maintenance; Wnt signaling pathway