CCL20 recombinant protein

CCL20 Protein, Mouse, Recombinant

Cat. Num. AAA8122499

• Gene Names: Ccl20; CKb4; LARC; ST38; MIP3A; MIP-3A; Scya20; MIP-3[a]; exodus-1
• Purity: >95% as determined by SDS-PAGE
• Synonyms: CCL20; CCL20 Protein; Mouse; Recombinant; Mouse CCL20/MIP-3 alpha/MIP3A protein; CKb4 Protein; exodus-1 Protein; LARC Protein; MIP-3A Protein; MIP-3[a] Protein; MIP3A Protein; Scya20 Protein; ST38 Protein; chemokine (C-C motif) ligand 20; CCL20 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Ala28-Met97

• Species: Mouse
• Predicted N Terminal: Met
• Tag: Native
• Protein Construction: A DNA sequence encoding the mouse CCL20 (NP_058656.1)(Ala28-Met97) was expressed with an initial Met.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for CCL20 recombinant protein

Background: Chemokine (C-C motif) ligand 2 (CCL2) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family that attracts immature dendritic cells and memory T lymphocytes, both expressing CCR6. Depending on the cell type, this chemokine was found to be inducible by cytokines (IL-1beta) and by bacterial, viral, or plant products (including LPS, dsRNA, and PMA). MIP3A/CCL2 is Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels of MIP3A/CCL2 has been seen in thymus, prostate, testis, small intestine and colon. As a chemotactic factor, MIP3A/CCL2 attracts lymphocytes and, slightly, neutrophils, but not monocytes. This chemokine may Inhibit proliferation of myeloid progenitors in colony formation assays and it may be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. Its C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Chemokine CCL2 was shown to play a role in colorectal cancer (CRC) pathogenesis.

Product Categories/Family for CCL20 recombinant protein

IL17 signaling pathway

References

Vicinus B, et al. (2012) miR-21 functionally interacts with the 3'UTR of chemokine CCL20 and down-regulates CCL20 expression in miR-21 transfected colorectal cancer cells. Cancer Lett. 316(1): 105-12.Ding X, et al. (2012) High Expression of CCL20 Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma after Curative Resection. J Gastrointest Surg. 16(4): 828-36.Ivison SM, et al. (2010) Oxidative stress enhances IL-8 and inhibits CCL20 production from intestinal epithelial cells in response to bacterial flagellin. Am J Physiol Gastrointest Liver Physiol. 299(3): 733-41.

NCBI and Uniprot Product Information

• NCBI GI #: 8394248
• NCBI GeneID: 20297
• NCBI Accession #: NP_058656.1
• NCBI GenBank Nucleotide #: NM_016960.2
• Molecular Weight: 10,755 Da
• NCBI Official Full Name: C-C motif chemokine 20 isoform 1
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 20
• NCBI Official Symbol: Ccl20
• NCBI Official Synonym Symbols: CKb4; LARC; ST38; MIP3A; MIP-3A; Scya20; MIP-3[a]; exodus-1
• NCBI Protein Information: C-C motif chemokine 20; MIP-3-alpha; CC chemokine LARC; CC chemokine ST38; beta chemokine exodus-1; beta-chemokine exodus-1; small-inducible cytokine A20; small inducible cytokine subfamily A20; macrophage inflammatory protein 3 alpha; liver and activatio
• Protein Family: C-C motif chemokine