C-C Motif Chemokine 18/CCL18/PARC Recombinant Protein | CCL18/PARC recombinant protein

Recombinant Human C-C Motif Chemokine 18/CCL18/PARC Protein (N-6His)

Cat. Num. AAA2552454

• Gene Names: CCL18; CKb7; PARC; AMAC1; DCCK1; MIP-4; AMAC-1; DC-CK1; SCYA18
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: C-C Motif Chemokine 18/CCL18/PARC; Recombinant Human C-C Motif Chemokine 18/CCL18/PARC Protein (N-6His); C-C Motif Chemokine 18; Alternative Macrophage Activation-Associated CC Chemokine 1; AMAC-1; CC Chemokine PARC; Dendritic Cell Chemokine 1; DC-CK1; Macrophage Inflammatory Protein 4; MIP-4; Pulmonary and Activation-Regulated Chemokine; Small-Inducible Cytokine A18; CCL18; AMAC1; DCCK1; MIP4; PARC; SCYA18; CCL18/PARC recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence Positions: Ala21-Ala89
• Sequence Length: 89

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: N-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for CCL18/PARC recombinant protein

C-C Motif Chemokine 18 (CCL18) is secreted protein that belongs to the intercrine beta (chemokine CC) family. CCL18 is expressed at high levels in the lung, lymph nodes, placenta, bone marrow, and dendritic cells. CCL18 is a chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. CCL18 may be involved in B-cell migration into B-cell follicles in lymph nodes. CCL18 attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.

NCBI and Uniprot Product Information

• NCBI GI #: 4506831
• NCBI GeneID: 6362
• NCBI Accession #: NP_002979.1
• NCBI GenBank Nucleotide #: NM_002988.3
• UniProt Accession #: P55774; Q53X71; B5BUM2
• Molecular Weight: Molecular Mass: 10.1 kDa; Actual Protein Molecular Mass: 13; 18 kDa
• NCBI Official Full Name: C-C motif chemokine 18
• NCBI Official Synonym Full Names: C-C motif chemokine ligand 18
• NCBI Official Symbol: CCL18
• NCBI Official Synonym Symbols: CKb7; PARC; AMAC1; DCCK1; MIP-4; AMAC-1; DC-CK1; SCYA18
• NCBI Protein Information: C-C motif chemokine 18
• UniProt Protein Name: C-C motif chemokine 18
• UniProt Gene Name: CCL18
• UniProt Synonym Gene Names: AMAC1; DCCK1; MIP4; PARC; SCYA18; AMAC-1; DC-CK1; MIP-4

NCBI Description

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]

Uniprot Description

Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.