TARC (CCL17) Recombinant Protein | TARC recombinant protein

Human TARC (CCL17) Recombinant

Cat. Num. AAA553219

• Purity: >98%, as determined by SDS-PAGE and HPLC
• Synonyms: TARC (CCL17); Human TARC (CCL17) Recombinant; ccl-17 ; CCL17; tarc; TARC recombinant protein

• Host: E Coli
• Purity/Purification: >98%, as determined by SDS-PAGE and HPLC
• Form/Format: Recombinant TARC was lyophilized from a 0.2 um filtered 20mM PB,100mM NaCl solution pH 7.5.
• Sequence: MAPLKMLALV TLLLGASLQH IHAARGTNVG RECCLEYFKG AIPLRKLKTW YQTSEDCSRD AIVFVTVQGR AICSDPNNKR VKNAVKYLQS LERS
• Sequence Length: 94

• Domain: IL8
• Host Note: Optimized DNA sequence encoding Human TARC (CCL17) mature chain was expressed in Escherichia Coli.
• Endotoxin: Endotoxin content was assayed using a LAL gel clot method.; Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
• Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
• Molecular Weight Note: Human CCL-17, generated by the proteolytic removal of the signal peptide; and propeptide and has a calculated molecular mass of approximately 8kDa.; ; Recombinant TARC is a disulfide-linked monomeric protein consisting of 72 amino acid residue subunits and migrates as an approximately 8 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE.
• Preparation and Storage: The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.; Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity. ; ; Avoid repeated freeze/thaw cycles.

Related Product Information for TARC recombinant protein

Thymus and activation- regulated chemokine (TARC) is a recently identified CC chemokine that is expressed constitutively in thymus and transiently in stimulated peripheral blood mononuclear cells. TARC functions as a selective chemoattractant for T cells that express a class of receptors binding TARC with high affinity and specificity.The chemokine TARC is a ligand for the chemokine receptor CCR4 expressed on T helper (Th) 2- type CD4 T cells.

Product Categories/Family for TARC recombinant protein

Cytokines

References

• il-12 produced by dendritic cells augments cd8+ t cell activation through the production of the chemokines ccl1 and CCL17 .J. Immunol., Dec 2008; 181: 8576 - 8584.
• clinical significance of serum tarc/CCL17 in atll patients: high tarc/CCL17 level is a significant unfavorable prognostic factor .Blood (ASH Annual Meeting Abstracts), Nov 2008; 112: 2821.
• respiratory syncytial virus synergizes with th2 cytokines to induce optimal levels of tarc/CCL17 .J. Immunol., Aug 2007; 179: 1648 - 1658.
• circulating thymus- and activation-regulated chemokine/CCL17 is a useful biomarker for discriminating acute eosinophilic pneumonia from other causes of acute lung injury .Chest, Jun 2007; 131: 1726 - 1734.
• evidence that phospholipase c-dependent, calcium-independent mechanisms are required for directional migration of t lymphocytes in response to the ccr4 ligands CCL17 and ccl22 .J. Leukoc. Biol., Jun 2006; 79: 1369 - 1380.