DBIRD complex subunit KIAA1967 homolog Recombinant Protein | Ccar2 recombinant protein

Recombinant Mouse DBIRD complex subunit KIAA1967 homolog , partial

• Gene Names: Ccar2; Dbc1; mKIAA1967; 2610301G19Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: DBIRD complex subunit KIAA1967 homolog; Recombinant Mouse DBIRD complex subunit KIAA1967 homolog; partial; Ccar2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 922

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 226958577
• NCBI GeneID: 219158
• NCBI Accession #: NP_666167.3
• NCBI GenBank Nucleotide #: NM_146055.3
• UniProt Accession #: Q8VDP4; Q6PIB1; Q8BWR5; Q8C0F0; Q8R3G6
• Molecular Weight: 103,002 Da
• NCBI Official Full Name: cell cycle and apoptosis regulator protein 2
• NCBI Official Synonym Full Names: cell cycle activator and apoptosis regulator 2
• NCBI Official Symbol: Ccar2
• NCBI Official Synonym Symbols: Dbc1; mKIAA1967; 2610301G19Rik
• NCBI Protein Information: cell cycle and apoptosis regulator protein 2
• UniProt Protein Name: Cell cycle and apoptosis regulator protein 2
• Protein Family: Cell cycle and apoptosis regulator protein
• UniProt Gene Name: Ccar2

Uniprot Description

Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (). As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors (). Inhibits SUV39H1 methyltransferase activity. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress () Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation. Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the ligand-dependent transcriptional activation function of ESR2. Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway. Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3. Represses the transcriptional activator activity of BRCA1. Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro ().