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Testing Data

CBR4 recombinant protein

CBR4; human recombinant

Gene Names
CBR4; SDR45C1
Applications
SDS-Page
Purity
> 95%
Synonyms
CBR4; human recombinant; Carbonyl reductase family member 4; Quinone reductase CBR4; 3-oxoacyl-[acyl-carrier-protein] reductase; CBR4 recombinant protein
Ordering
For Research Use Only!
Host
E Coli
Source: Human
Purity/Purification
> 95%
Form/Format
Liquid
In 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol; 5 mM DTT; 200 mM NaCl
Sequence
MGSSHHHHHH SSGLVPRGSH MDKVCAVFGG SRGIGRAVAQ LMARKGYRLA VIARNLEGAK AAAGDLGGDH LAFSCDVAKE HDVQNTFEEM EKHLGRVNFL VNAAGINRDG LLVRTKTEDM VSQLHTNLLG SMLTCKAAMR TMIQQQGGSI VNVGSIVGLK GNSGQSVYSA SKGGLVGFSR ALAKEVARKK IRVNVVAPGF VHTDMTKDLK EEHLKKNIPL GRFGETIEVA HAVVFLLESP YITGHVLVVD GGLQLIL
Sequence Length
237
Applicable Applications for CBR4 recombinant protein
SDS-PAGE
Preparation and Storage
Store at -20 degree C for 12 months.
Centrifuge the vial prior to opening.

Testing Data

Testing Data
Related Product Information for CBR4 recombinant protein
CBR4 belongs to the short-chain dehydrogenase/reductase family. The formation of heteroteramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity for o- and p-quinones. It plays a role in biosynthesis of fatty acids in mitochondria and has broad substrate specificity and reduces 9; 10-phenanthrenequinone; 1; 4-benzoquinone and various other o-quinones and p-quinones (in vitro). Recombinant human CBR4 protein; fused to His-tag at N-terminus; was expressed in E Coli and purified by using conventional chromatography techniques.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
27.5 kDa
NCBI Official Full Name
carbonyl reductase family member 4
NCBI Official Synonym Full Names
carbonyl reductase 4
NCBI Official Symbol
CBR4
NCBI Official Synonym Symbols
SDR45C1
NCBI Protein Information
carbonyl reductase family member 4
UniProt Protein Name
Carbonyl reductase family member 4
Protein Family
UniProt Gene Name
CBR4
UniProt Synonym Gene Names
SDR45C1; KAR beta subunit

Uniprot Description

CBR4: The heteroteramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro). Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.-.-.-; EC 1.1.1.-; Mitochondrial; Oxidoreductase

Chromosomal Location of Human Ortholog: 4q32.3

Cellular Component: mitochondrial matrix

Molecular Function: 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity; NAD(P)H dehydrogenase (quinone) activity; NADPH dehydrogenase (quinone) activity; protein binding; quinone binding

Biological Process: acyl-CoA biosynthetic process; fatty acid biosynthetic process; protein heterotetramerization; protein homotetramerization

Research Articles on CBR4

Similar Products

Product Notes

The CBR4 cbr4 (Catalog #AAA847084) is a Recombinant Protein produced from E Coli Source: Human and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's CBR4 can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE. Researchers should empirically determine the suitability of the CBR4 cbr4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MGSSHHHHHH SSGLVPRGSH MDKVCAVFGG SRGIGRAVAQ LMARKGYRLA VIARNLEGAK AAAGDLGGDH LAFSCDVAKE HDVQNTFEEM EKHLGRVNFL VNAAGINRDG LLVRTKTEDM VSQLHTNLLG SMLTCKAAMR TMIQQQGGSI VNVGSIVGLK GNSGQSVYSA SKGGLVGFSR ALAKEVARKK IRVNVVAPGF VHTDMTKDLK EEHLKKNIPL GRFGETIEVA HAVVFLLESP YITGHVLVVD GGLQLIL. It is sometimes possible for the material contained within the vial of "CBR4, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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