Rat E3 ubiquitin-protein ligase CBL-B ELISA Kit | Cblb elisa kit
Rat E3 ubiquitin-protein ligase CBL-B ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
ubiquitin-protein ligase; may regulate autoimmunity; implicated as a susceptibility gene for type I diabetes (IDDM) [RGD, Feb 2006]
Uniprot Description
Cbl-b: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B- cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T- cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization. Interacts with SH3 domain-containing proteins LCK, CRK and SORBS1. Interacts with LCP2 and ZAP70. May interact with CBL. Interacts with SH3 domain-containing proteins VAV1, FYN, FGR, PLCG1, GRB2, CRKL, PIK3R1 and SH3KBP1/CIN85. Identified in heterotrimeric complexes with SH3KBP1/CIN85, CD2AP and ARHGEF7, where one CBLB peptide binds two copies of the other protein. Interacts with poly-ubiquitinated proteins. Dimerization is required for the binding of poly-ubiquitin, but not for the binding of mono-ubiquitin. Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle. Present in lymphocytes. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Ligase; Ubiquitin ligase; Adaptor/scaffold; EC 6.3.2.-; Ubiquitin conjugating system; Calcium-binding
Cellular Component: cytoplasm; lipid raft; nucleoplasm; nucleus
Molecular Function: calcium ion binding; ligase activity; phosphotyrosine binding; protein kinase binding; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding
Biological Process: cell surface receptor linked signal transduction; immune response; negative regulation of alpha-beta T cell proliferation; negative regulation of T cell receptor signaling pathway; positive regulation of protein catabolic process; positive regulation of T cell anergy; protein ubiquitination; response to gravity; response to hormone stimulus; signal transduction; T cell activation
Research Articles on Cblb
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Product Notes
The Rat Cblb cblb (Catalog #AAA2884160) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2884160 ELISA Kit recognizes Rat Cblb. It is sometimes possible for the material contained within the vial of "E3 ubiquitin-protein ligase CBL-B, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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