Protein CBFA2T3 (CBFA2T3) Recombinant Protein | CBFA2T3 recombinant protein

Recombinant Human Protein CBFA2T3 (CBFA2T3)

Cat. Num. AAA1080491

• Gene Names: CBFA2T3; ETO2; MTG16; MTGR2; ZMYND4; RUNX1T3
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Protein CBFA2T3 (CBFA2T3); Recombinant Human Protein CBFA2T3 (CBFA2T3); CBFA2T3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-653, Full length protein
• Sequence: MPASRLRDRAASSASGSTCGSMSQTHPVLESGLLASAGCSAPRGPRKGGPAPVDRKAKASAMPDSPAEVKTQPRSTPPSMPPPPPAASQGATRPPSFTPHTHREDGPATLPHGRFHGCLKWSMVCLLMNGSSHSPTAINGAPCTPNGFSNGPATSSTASLSTQHLPPACGARQLSKLKRFLTTLQQFGSDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQTPAQYLAQHEQLLLDASASSPIDSSELLLEVNENGKRRTPDRTKENGSDRDPLHPEHLSKRPCTLNPAQRYSPSNGPPQPTPPPHYRLEDIAMAHHFRDAYRHPDPRELRERHRPLVVPGSRQEEVIDHKLTEREWAEEWKHLNNLLNCIMDMVEKTRRSLTVLRRCQEADREELNHWARRYSDAEDTKKGPAPAAARPRSSSAGPEGPQLDVPREFLPRTLTGYVPEDIWRKAEEAVNEVKRQAMSELQKAVSDAERKAHELITTERAKMERALAEAKRQASEDALTVINQQEDSSESCWNCGRKASETCSGCNAARYCGSFCQHRDWEKHHHVCGQSLQGPTAVVADPVPGPPEAAHSLGPSLPVGAASPSEAGSAGPSRPGSPSPPGPLDTVPR
• Sequence Length: 653

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for CBFA2T3 recombinant protein

The t(16;21)(q24;q22) translocation is a rare but recurrent chromosomal abnormality associated with therapy-related myeloid malignancies. The translocation produces a chimeric gene made up of the 5 -region of the AML1 gene fused to the 3 -region of this gene. In addition, this gene is a putative breast tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene, and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi apparatus.

NCBI and Uniprot Product Information

• NCBI GI #: 28872803
• NCBI GeneID: 863
• NCBI Accession #: NP_005178.4
• NCBI GenBank Nucleotide #: NM_005187.5
• UniProt Accession #: O75081; O60615; O60616; O60617; O75082; O75107; O75108; Q0P5Z6; Q6P5W6; D3DX78
• Molecular Weight: 7,436 Da
• NCBI Official Full Name: protein CBFA2T3 isoform 1
• NCBI Official Synonym Full Names: CBFA2/RUNX1 translocation partner 3
• NCBI Official Symbol: CBFA2T3
• NCBI Official Synonym Symbols: ETO2; MTG16; MTGR2; ZMYND4; RUNX1T3
• NCBI Protein Information: protein CBFA2T3
• UniProt Protein Name: Protein CBFA2T3
• Protein Family: Protein
• UniProt Gene Name: CBFA2T3
• UniProt Synonym Gene Names: MTG16; MTGR2; ZMYND4; hMTG16

NCBI Description

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

Uniprot Description

Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (). Plays a role in granulocyte differentiation (PubMed:15231665).