Cavy Probable Ubiquitin Carboxyl-Terminal Hydrolase FAF-X (USP9X) ELISA Kit | USP9X elisa kit

Cavy Probable Ubiquitin Carboxyl-Terminal Hydrolase FAF-X (USP9X) ELISA Kit

• Gene Names: USP9X; FAF; FAM; DFFRX; MRX99; MRXS99F
• Reactivity: Cavy
• Synonyms: Probable Ubiquitin Carboxyl-Terminal Hydrolase FAF-X (USP9X); Cavy Probable Ubiquitin Carboxyl-Terminal Hydrolase FAF-X (USP9X) ELISA Kit; USP9X elisa kit

• Reactivity: Cavy

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 145309311
• NCBI GeneID: 8239
• NCBI Accession #: NP_001034680.2
• NCBI GenBank Nucleotide #: NM_001039591.2
• Molecular Weight: 290,463 Da
• NCBI Official Full Name: probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform 4
• NCBI Official Synonym Full Names: ubiquitin specific peptidase 9, X-linked
• NCBI Official Symbol: USP9X
• NCBI Official Synonym Symbols: FAF; FAM; DFFRX; MRX99; MRXS99F
• NCBI Protein Information: probable ubiquitin carboxyl-terminal hydrolase FAF-X
• UniProt Protein Name: Probable ubiquitin carboxyl-terminal hydrolase FAF-X
• Protein Family: Probable ubiquitin carboxyl-terminal hydrolase
• UniProt Gene Name: USP9X
• UniProt Synonym Gene Names: DFFRX; FAM; USP9; hFAM
• UniProt Entry Name: USP9X_HUMAN

NCBI Description

This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

USP9X: Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Specifically hydrolyzes both 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Interacts with SMAD4, MARK4, NUAK1 and BIRC5/survivin. Widely expressed in embryonic and adult tissues. Belongs to the peptidase C19 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Ubiquitin conjugating system; EC 3.4.19.12; Ubiquitin-specific protease

Chromosomal Location of Human Ortholog: Xp11.4

Cellular Component: apical part of cell; cytoplasm; cytosol; growth cone; membrane

Molecular Function: cysteine-type endopeptidase activity; cysteine-type peptidase activity; protein binding; ubiquitin-specific protease activity

Biological Process: axon extension; BMP signaling pathway; cell division; cellular protein metabolic process; cerebellar cortex structural organization; chromosome segregation; female gamete generation; gene expression; hippocampus development; in utero embryonic development; mitosis; negative regulation of transcription from RNA polymerase II promoter; neuron migration; post-embryonic development; protein deubiquitination; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; ubiquitin-dependent protein catabolic process

Disease: Mental Retardation, X-linked 99