Typical Testing Data/Standard Curve (for reference only)
Human Calsequestrin-1 ELISA Kit | CASQ1 elisa kit
Human Calsequestrin-1 ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the skeletal muscle specific member of the calsequestrin protein family. Calsequestrin functions as a luminal sarcoplasmic reticulum calcium sensor in both cardiac and skeletal muscle cells. This protein, also known as calmitine, functions as a calcium regulator in the mitochondria of skeletal muscle. This protein is absent in patients with Duchenne and Becker types of muscular dystrophy. [provided by RefSeq, Jun 2013]
Uniprot Description
calsequestrin 1: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+). Belongs to the calsequestrin family.
Protein type: Mitochondrial; Calcium-binding
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: endoplasmic reticulum; Golgi apparatus; I band; mitochondrial matrix; mitochondrion; sarcoplasmic reticulum; sarcoplasmic reticulum lumen; sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; T-tubule
Molecular Function: calcium ion binding
Biological Process: endoplasmic reticulum organization and biogenesis; protein polymerization; regulation of skeletal muscle contraction via regulation of the release of sequestered calcium ion; response to denervation involved in regulation of muscle adaptation; response to heat; response to organic substance; sarcomere organization; skeletal muscle development; transmembrane transport
Disease: Myopathy, Vacuolar, With Casq1 Aggregates
Research Articles on CASQ1
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Product Notes
The Human CASQ1 casq1 (Catalog #AAA2880590) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2880590 ELISA Kit recognizes Human CASQ1. It is sometimes possible for the material contained within the vial of "Calsequestrin-1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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