Leucine-rich repeat-containing protein 16C (RLTPR) Recombinant Protein | RLTPR recombinant protein

Recombinant Human Leucine-rich repeat-containing protein 16C (RLTPR) , partial

• Gene Names: CARMIL2; RLTPR; LRRC16C; CARMIL2b
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Leucine-rich repeat-containing protein 16C (RLTPR); Recombinant Human Leucine-rich repeat-containing protein 16C (RLTPR); partial; RLTPR recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1435

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 66392157
• NCBI GeneID: 146206
• NCBI Accession #: NP_001013860.1
• NCBI GenBank Nucleotide #: NM_001013838.2
• UniProt Accession #: Q6F5E8; B8X2Z3
• Molecular Weight: 148,208 Da
• NCBI Official Full Name: capping protein, Arp2/3 and myosin-I linker protein 2 isoform 1
• NCBI Official Synonym Full Names: capping protein regulator and myosin 1 linker 2
• NCBI Official Symbol: CARMIL2
• NCBI Official Synonym Symbols: RLTPR; LRRC16C; CARMIL2b
• NCBI Protein Information: capping protein, Arp2/3 and myosin-I linker protein 2; F-actin-uncapping protein RLTPR
• UniProt Protein Name: Capping protein, Arp2/3 and myosin-I linker protein 2
• UniProt Gene Name: CARMIL2

NCBI Description

This gene encodes a member of the CARMIL (capping protein, Arp2/3, myosin-I linker) family of proteins. The encoded protein interacts with and negatively regulates the heterodimeric capping protein and promotes cell migration. Reduced expression of this gene has been observed in human psoriasis patients. Mutations in this gene cause a human immunodeficiency syndrome characterized by smooth muscle tumors and impaired T-cell function. [provided by RefSeq, May 2017]

Uniprot Description

Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26578515, PubMed:26466680). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26578515, PubMed:26466680).