CAP1 recombinant protein

Recombinant Human CAP1 protein

Cat. Num. AAA1561946

• Gene Names: CAP1; CAP; CAP1-PEN
• Purity: >90% as determined by SDS-PAGE
• Synonyms: CAP1; Recombinant Human CAP1 protein; Adenylyl cyclase-associated protein 1; CAP 1; CAP1 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human CAP1 (Lys317-Glu455) was fused with His tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for CAP1 recombinant protein

Prostasin (Prss8), also known as channel activating protease 1 (CAP1), is a trypsinlike serine peptidase, and plays important roles in epithelial physiology. It is originally purified as an active, soluble enzyme from human seminal fluid and is highly expressed in prostate, lung, kidney, salivary gland and pancreas. Prostasin is expressed as a glycosyl-phosphatidylinositol (GPI)-anchored membrane protein in prostate epithelial cells, and also exists as a secreted proteolytic enzyme possibly via tryptic cleavage of its COOH-terminal hydrophobic domain. Prostasin is found to activate the epithelial sodium channel (ENaC) which is tightly regulated and is critical for maintaining salt and fluid balance in the lung and kidney in both normal and pathological conditions. Accordingly, prostasin has been proposed as a target for therapeutic inhibition in cystic fibrosis. In addition, prostasin inhibits prostate and breast cancer cell invasion in vitro, suggesting a functional role as a suppressor of tumor invasion, as well as a regulator of gene expression during inflammation.

Product Categories/Family for CAP1 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 308153681
• NCBI GeneID: 10487
• UniProt Accession #: Q01518; Q53HR7; Q5T0S1; Q5T0S2; Q6I9U6
• Molecular Weight: 475
• NCBI Official Full Name: Adenylyl cyclase-associated protein 1
• NCBI Official Synonym Full Names: CAP, adenylate cyclase-associated protein 1 (yeast)
• NCBI Official Symbol: CAP1
• NCBI Official Synonym Symbols: CAP; CAP1-PEN
• NCBI Protein Information: adenylyl cyclase-associated protein 1; CAP 1
• UniProt Protein Name: Adenylyl cyclase-associated protein 1
• Protein Family: CAP1-binding-protein
• UniProt Gene Name: CAP1
• UniProt Synonym Gene Names: CAP; CAP 1
• UniProt Entry Name: CAP1_HUMAN

NCBI Description

The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

CAP1: an actin binding protein. Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.

Protein type: Actin-binding; Cytoskeletal

Chromosomal Location of Human Ortholog: 1p34.2

Cellular Component: cortical actin cytoskeleton; focal adhesion; plasma membrane

Molecular Function: actin binding

Biological Process: axon guidance; platelet activation; receptor-mediated endocytosis; platelet degranulation; ameboidal cell migration; adenylate cyclase activation; establishment and/or maintenance of cell polarity; signal transduction; blood coagulation; actin cytoskeleton organization and biogenesis